INT183634

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 6.25
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Macf1) ATPase activity (Macf1) plasma membrane (Macf1)
cytoskeleton (Macf1) cytoplasm (Macf1)
Macf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 8 81.92 Quite High
Inflammation 14 78.00 Quite High
Bile 1 66.00 Quite High
COX-2 inhibitor 5 50.00 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 133 100.00 Very High Very High Very High
Targeted Disruption 240 99.80 Very High Very High Very High
Cancer 299 96.80 Very High Very High Very High
Inflammatory Bowel Disease 25 94.16 High High
Carcinoma 11 93.80 High High
Adenoma 112 93.20 High High
Colon Cancer 143 91.52 High High
Colitis 17 88.56 High High
INFLAMMATION 11 78.00 Quite High
Apoptosis 59 67.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increase in ACF was especially prominent for those consisting of ?
Positive_regulation (increase) of ACF associated with aberrant crypt foci
1) Confidence 0.13 Published 2006 Journal J Carcinog Section Abstract Doc Link PMC1660565 Disease Relevance 1.67 Pain Relevance 0
In the late stage of carcinogenesis at 40 weeks after the first DMH application, especially in the IGF-II transgenic mice the occurrence of the ACF was found to be drastically reduced (P < 0.001) versus the earlier stage (Fig. 2B).
Positive_regulation (occurrence) of ACF associated with aberrant crypt foci and targeted disruption
2) Confidence 0.11 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.38 Pain Relevance 0
three AC remained constant over time, whereas the reduction in total number of ACF in both genotypes at a late stage was due to the reduced number in ACF containing one to three AC (Table 1).


Positive_regulation (due) of ACF associated with aberrant crypt foci
3) Confidence 0.10 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.97 Pain Relevance 0
ligands inhibits AOM and/or DSS-induced ACF in rodents [38].
Positive_regulation (induced) of ACF associated with aberrant crypt foci
4) Confidence 0.05 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1156872 Disease Relevance 1.23 Pain Relevance 0.38

General Comments

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