INT183635

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 10.00
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 295 100.00 Very High Very High Very High
antagonist 6 99.36 Very High Very High Very High
cytokine 57 97.20 Very High Very High Very High
agonist 99 95.48 Very High Very High Very High
cINOD 23 87.24 High High
Bile 2 63.68 Quite High
COX-2 inhibitor 7 50.00 Quite Low
psoriasis 3 31.04 Quite Low
Inflammatory response 25 5.00 Very Low Very Low Very Low
COX2 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 417 100.00 Very High Very High Very High
INFLAMMATION 324 100.00 Very High Very High Very High
Repression 15 100.00 Very High Very High Very High
Hyperlipidemia 12 100.00 Very High Very High Very High
Cancer 499 99.98 Very High Very High Very High
Aberrant Crypt Foci 8 98.12 Very High Very High Very High
Metastasis 21 96.76 Very High Very High Very High
Reprotox - General 1 4 96.64 Very High Very High Very High
Hyperplasia 15 95.12 Very High Very High Very High
Inflammatory Bowel Disease 48 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In OVX mice, E2 inhibited the actions of fenofibrate-activated PPAR?
Negative_regulation (inhibited) of Positive_regulation (activated) of PPAR
1) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.41 Pain Relevance 0
However, the expression levels were much higher in males than in females, suggesting that fenofibrate exhibits sexually dimorphic activation of PPAR?
Negative_regulation (dimorphic) of Positive_regulation (activation) of PPAR
2) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.57 Pain Relevance 0
Together these findings support the importance of PPAR?
Negative_regulation (support) of Positive_regulation (importance) of PPAR
3) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.33 Pain Relevance 0
Conversely, the results underscore the importance of PPAR?
Negative_regulation (underscore) of Positive_regulation (importance) of PPAR
4) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.48 Pain Relevance 0
may inhibit the activation of PPAR?
Negative_regulation (inhibit) of Positive_regulation (activation) of PPAR
5) Confidence 0.42 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.09 Pain Relevance 0
-1

signaling is responsible for the repression of inflammatory-induced PPAR?

Negative_regulation (repression) of Positive_regulation (induced) of PPAR associated with inflammation and repression
6) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 1.00 Pain Relevance 0.25
reported that ligand activation of PPAR?
Negative_regulation (reported) of Positive_regulation (activation) of PPAR
7) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.54 Pain Relevance 0.05
Surprisingly, troglitazone treatment significantly reduced irradiation-induced PPAR-?
Negative_regulation (reduced) of Positive_regulation (induced) of PPAR
8) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.41 Pain Relevance 0.12
In conclusion, fenofibrate prevents both obesity and hypertriglyceridemia through hepatic PPAR?
Negative_regulation (prevents) of Positive_regulation (hepatic) of PPAR associated with obesity and hyperlipidemia
9) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.98 Pain Relevance 0
In the present study, cancer chemopreventive ability of the PPAR?
Negative_regulation (chemopreventive) of Positive_regulation (ability) of PPAR associated with cancer
10) Confidence 0.35 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1156872 Disease Relevance 1.13 Pain Relevance 0.41
Although the possible involvement of PPAR-?
Spec (possible) Negative_regulation (possible) of Spec (possible) Positive_regulation (involvement) of PPAR
11) Confidence 0.27 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.34 Pain Relevance 0.15
The mechanism of pyMT-induced tumorigenesis was believed to be through a partial impairment of activated PPAR?
Spec (partial) Negative_regulation (impairment) of Spec (partial) Positive_regulation (activated) of PPAR
12) Confidence 0.23 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.66 Pain Relevance 0
antagonist, showed that downregulation or blocking the activation of PPAR?
Negative_regulation (blocking) of Positive_regulation (activation) of PPAR associated with antagonist
13) Confidence 0.20 Published 2009 Journal PPAR Research Section Body Doc Link PMC2651001 Disease Relevance 0.05 Pain Relevance 0.23

General Comments

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