INT18365

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.74
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 62 100.00 Very High Very High Very High
antagonist 9 99.96 Very High Very High Very High
agonist 6 99.96 Very High Very High Very High
Morphine 13 99.60 Very High Very High Very High
Nucleus accumbens 2 97.78 Very High Very High Very High
cerebral cortex 37 96.36 Very High Very High Very High
opioid receptor 1 90.88 High High
Substantia nigra 3 85.32 High High
dexamethasone 3 79.76 Quite High
anesthesia 1 75.92 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 99.98 Very High Very High Very High
Hypertension 9 96.00 Very High Very High Very High
Diuresis 1 86.64 High High
Natriuresis 2 86.12 High High
Cognitive Disorder 11 76.32 Quite High
Sprains And Strains 1 63.04 Quite High
INFLAMMATION 1 62.68 Quite High
Stress 9 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of the dopamine-2 antagonist YM-09151 to the dopamine-1 antagonist infusion did not enhance the effect of the dopamine-1 antagonist.
Neg (not) Positive_regulation (enhance) of Regulation (effect) of dopamine-1 associated with dopamine and antagonist
1) Confidence 0.50 Published 1990 Journal Hypertension Section Abstract Doc Link 1971811 Disease Relevance 0.94 Pain Relevance 1.00
Treatment of primary neuronal cultures of the rat striatal complex (striatum/nucleus accumbens, consisting for more than 90% of gamma-aminobutyric acid neurons) with 10 microM morphine for 2 hr to 3 days, enhanced the maximal stimulatory effect of the dopamine D-1 receptor agonist SKF38393 on adenylyl cyclase activity.
Positive_regulation (enhanced) of Regulation (effect) of D-1 receptor in neurons associated with nucleus accumbens, dopamine, agonist and morphine
2) Confidence 0.40 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562482 Disease Relevance 0 Pain Relevance 0.68
It is concluded that chronic morphine treatment probably induces a down regulation of nigral D-1 and D-2 binding sites and reduces the negative feed-back mechanisms triggered by DA autoreceptors.
Positive_regulation (induces) of Regulation (regulation) of D-1 associated with dopamine and morphine
3) Confidence 0.25 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2456939 Disease Relevance 0 Pain Relevance 0.91
We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control.
Positive_regulation (induced) of Regulation (alteration) of dopamine D1 associated with dopamine and diabetes mellitus
4) Confidence 0.23 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.80 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox