INT18366

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Context Info
Confidence 0.42
First Reported 1985
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 0.49
Pain Relevance 5.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 4
neuronal 2
striatum 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 446 100.00 Very High Very High Very High
dopamine receptor 122 100.00 Very High Very High Very High
gABA 105 100.00 Very High Very High Very High
antagonist 56 100.00 Very High Very High Very High
substance P 2 99.68 Very High Very High Very High
opioid receptor 5 99.44 Very High Very High Very High
agonist 103 98.80 Very High Very High Very High
narcan 3 98.80 Very High Very High Very High
Dynorphin 3 98.60 Very High Very High Very High
nMDA receptor 5 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 9 96.32 Very High Very High Very High
Targeted Disruption 8 87.12 High High
Sprains And Strains 1 81.28 Quite High
Natriuresis 2 47.20 Quite Low
Diuresis 1 34.24 Quite Low
Disease 88 22.24 Low Low
Parkinson's Disease 84 13.12 Low Low
Attention Deficit Hyperactivity Disorder 12 10.76 Low Low
Urological Neuroanatomy 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of renal dopamine-1 receptors decreases sodium transport.
Negative_regulation (decreases) of Positive_regulation (Activation) of dopamine-1 associated with dopamine
1) Confidence 0.42 Published 1990 Journal Hypertension Section Abstract Doc Link 1971811 Disease Relevance 0.40 Pain Relevance 0.32
Upon selective D-1 dopamine receptor activation with 30 microM dopamine in the presence of 10 microM of the D-2 dopamine receptor antagonist (-)sulpiride, the enhanced efflux of cyclic AMP was reduced by all three opioid receptor agonists, but only the effect of morphine was antagonized by 0.1 microM naloxone.
Negative_regulation (reduced) of Positive_regulation (activation) of D-1 dopamine receptor associated with dopamine, antagonist, dopamine receptor, narcan, agonist, opioid receptor and morphine
2) Confidence 0.33 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2417870 Disease Relevance 0 Pain Relevance 1.13
Treatment with a D2 receptor antagonist (eticlopride; 1 mg/kg/day) for 7 days reduced D1 receptor stimulation of adenylyl cyclase.
Negative_regulation (reduced) of Positive_regulation (stimulation) of D1 receptor associated with antagonist
3) Confidence 0.29 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353370 Disease Relevance 0 Pain Relevance 0.91
However, it induced a decreased response to dopamine D1-receptor stimulation in the substance P mRNA levels in dorsal regions of the dopamine-depleted striatum.
Negative_regulation (decreased) of Positive_regulation (stimulation) of D1-receptor in striatum associated with dopamine and substance p
4) Confidence 0.20 Published 2002 Journal Synapse Section Abstract Doc Link 11746728 Disease Relevance 0 Pain Relevance 0.92
Moreover, our data indicate that activation of G-protein-coupled dopamine D1 receptors also induces a transporter-mediated increase in spontaneous GABA release, but through a different mechanism of action, i.e., through cAMP-dependent inhibition of Na(+)/K(+)-ATPase, inducing accumulation of intracellular sodium, reversal of the GABA carrier, and potentiation of NMDA-induced release.
Negative_regulation (inhibition) of Positive_regulation (activation) of dopamine D1 associated with gaba and dopamine
5) Confidence 0.17 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10777812 Disease Relevance 0 Pain Relevance 1.10
Overall, dopamine appears to decrease the neuronal activity in the GPi, likely via activation of D1LRs (Table 2).
Spec (likely) Negative_regulation (decrease) of Positive_regulation (activation) of D1LRs in neuronal associated with dopamine
6) Confidence 0.05 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.09 Pain Relevance 0.27
Not all studies have agreed that the activation of D1LRs increases GABA release and reduces the activity of neurons in the SNr.
Negative_regulation (reduces) of Positive_regulation (activation) of D1LRs in neurons associated with gaba
7) Confidence 0.04 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.38
Our recent primate recording experiments have confirmed that the local activation of D1LRs in the SNr reduces the activity of SNr neurons (Kliem et al., 2007a).
Negative_regulation (reduces) of Positive_regulation (activation) of D1LRs in neurons
8) Confidence 0.04 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.23
For instance, our primate studies have demonstrated that activation of D1LRs in GPi and SNr leads to an inhibition of firing, most likely explained through increased GABA release in these nuclei.
Spec (likely) Negative_regulation (inhibition) of Positive_regulation (activation) of D1LRs associated with gaba
9) Confidence 0.04 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.27

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