INT183672

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 37
Total Number 41
Disease Relevance 28.68
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (EPAS1) signal transduction (EPAS1) mitochondrion organization (EPAS1)
nucleus (EPAS1) DNA binding (EPAS1) transcription factor binding (EPAS1)
Anatomy Link Frequency
tendon 8
tears 7
endothelial cell 1
stage 1 1
MCF-7 1
EPAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 84 98.80 Very High Very High Very High
methotrexate 9 90.76 High High
rheumatoid arthritis 31 77.68 Quite High
alcohol 56 73.64 Quite High
Potency 3 66.88 Quite High
noradrenaline 4 62.48 Quite High
Pain 36 59.40 Quite High
imagery 109 52.08 Quite High
Catecholamine 35 51.04 Quite High
Dopamine 3 28.56 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 537 100.00 Very High Very High Very High
Cancer 597 99.98 Very High Very High Very High
Muscular Atrophy 560 99.88 Very High Very High Very High
Tendinopathy 56 99.76 Very High Very High Very High
Rotator Cuff Tears 560 99.32 Very High Very High Very High
Rupture 56 98.86 Very High Very High Very High
Osteoarthritis 84 98.80 Very High Very High Very High
Renal Cell Carcinoma 88 98.54 Very High Very High Very High
Solid Tumor 21 95.72 Very High Very High Very High
Toxicity 37 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, the expression of certain HIF target proteins is increased even when oxygen levels are normal.


Gene_expression (expression) of HIF
1) Confidence 0.35 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1479389 Disease Relevance 0.82 Pain Relevance 0
We demonstrated a correlation between FI and MA and VEGF/HIF expression.
Gene_expression (expression) of HIF associated with muscular atrophy
2) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.78 Pain Relevance 0.06
We assume that complete tendon rupture reduces mechanical cyclic loading, resulting in reduced HIF expression.
Gene_expression (expression) of HIF in tendon associated with rupture
3) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.60 Pain Relevance 0
Lewis et al. described increased neovascularity in patients with rotator cuff tendinopathy; increased HIF and VEGF expression in the diseased rotator cuff, but not in tendon retraction [12].
Gene_expression (expression) of HIF in tendon associated with tendinopathy
4) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.70 Pain Relevance 0
The purpose of this study is to examine HIF and VEGF expression, and neovascularity in torn rotator cuff tissue from patients with medium size (3-5 cm, formally Bateman stage 3) full-thickness tears and tendon retraction, compared with healthy control samples.
Spec (examine) Gene_expression (expression) of HIF in tendon
5) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.55 Pain Relevance 0
In our findings, HIF expression significantly increases with rising Patte grade.
Gene_expression (expression) of HIF
6) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.73 Pain Relevance 0
Cyclic loading is as important inducer of HIF expression.
Gene_expression (expression) of HIF
7) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.54 Pain Relevance 0
Therefore, it remains unclear whether hypoxia or cyclic tendon loading is the underlying reason for HIF and VEGF expression.
Gene_expression (expression) of HIF in tendon associated with hypoxia
8) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.89 Pain Relevance 0.06
Therefore, VEGF and HIF expression as well as neovascularity may be used as a monitoring tool in the clinical setting, for the level of tendon degeneration that occurs during tendon degeneration.
Gene_expression (expression) of HIF in tendon
9) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.83 Pain Relevance 0.06
HIF and VEGF expression was significantly elevated in groups II-IV (Patte stage 1-3) in comparison with controls (group I) (p = 0.045, Figure 4a-d).
Gene_expression (expression) of HIF in stage 1
10) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.18 Pain Relevance 0
If hypoxia underlies HIF expression, this contradicts Matthews's results describing the poorest blood supply in massive tears [15].
Gene_expression (expression) of HIF in tears associated with hypoxia
11) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.65 Pain Relevance 0
A second goal is to find an association between FI, MA and the amount of VEGF and HIF expression and neovascularity within both torn rotator cuffs.


Gene_expression (expression) of HIF associated with muscular atrophy
12) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.43 Pain Relevance 0
Osteoarthritis was not measured, but may act as a confounder for VEGF and HIF expression.
Gene_expression (expression) of HIF associated with osteoarthritis
13) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.96 Pain Relevance 0.10
HIF, which is induced by cell hypoxia, is one of the most important regulators of VEGF gene expression [28].
Gene_expression (expression) of HIF associated with hypoxia
14) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 1.15 Pain Relevance 0.04
We demonstrated a correlation between vessel density, VEGF, and HIF expression as well as FI and MA in full-thickness medium-sized rotator cuff tears and tendon retraction.
Gene_expression (expression) of HIF in tendon associated with rotator cuff tears and muscular atrophy
15) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.87 Pain Relevance 0.08
The aim of this study is to clarify the relationship between HIF and VEGF expression, neoangiogenesis, FI, and MA in tendon retraction found in full-thickness rotator cuff tears.


Gene_expression (expression) of HIF in tears associated with rotator cuff tears and muscular atrophy
16) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2958987 Disease Relevance 0.82 Pain Relevance 0
Patient demographics (age, gender), mean HIF and VEGF expression, vessel density, vessel size, and FI and MA classification schemes are outlined in Additional file 1.


Gene_expression (expression) of HIF associated with muscular atrophy
17) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.18 Pain Relevance 0.04
For immunohistological determination of VEGF and HIF expression, sample slices were strained with VEGF and HIF antibody dilution.
Gene_expression (expression) of HIF
18) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2958987 Disease Relevance 0.87 Pain Relevance 0
Tendon retraction in full-thickness medium-sized rotator cuff tears is characterized by neovascularity, increased VEGF/HIF expression, FI, and MA.
Gene_expression (expression) of HIF in tears associated with muscular atrophy and rotator cuff tears
19) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2958987 Disease Relevance 0.57 Pain Relevance 0
We aimed to clarity the relationship between VEGF/HIF expression and neovascularization and tendon retraction in full-thickness rotator cuff injuries.
Gene_expression (expression) of HIF in tendon associated with rotator cuff tears
20) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 0.45 Pain Relevance 0

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