INT183680

Context Info Confidence 0.71 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.69 Pain Relevance 0.39

endosome (Tlr3) signal transduction (Tlr3) endoplasmic reticulum (Tlr3) RNA binding (Tlr3) intracellular (Tlr3) cytoplasm (Tlr3)

Anatomy Link Frequency lungs 3 microglia 1 Tlr3 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 23 92.04 Inflammatory response 12 90.80 Inflammation 107 85.36 chemokine 117 79.92 agonist 27 55.68 Inflammatory mediators 4 49.84 adenocard 1 42.16 anesthesia 5 39.36 cytokine 53 21.28 ketamine 4 19.84

Disease Link Frequency Relevance Heat Influenza Virus Infection 92 94.40 Pressure And Volume Under Development 30 92.16 INFLAMMATION 99 90.40 Autoimmune Disease 4 87.68 Viral Infection 69 87.16 Injury 39 85.80 Bacterial Infection 2 85.72 Coccidioides Infection 3 80.72 Rabies Virus Infection 3 78.72 Togavirus Infection 1 75.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunolocalization of TLR3

Localization (Immunolocalization) of TLR3

1) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.09 Pain Relevance 0

Paraffin-embedded tissues from dsRNA-treated and ssRNA-treated lungs were processed for immunohistochemical localization of Toll-like receptor 3 (TLR3) expression using a method previously described [33,39].

Localization (localization) of TLR3 in lungs

2) Confidence 0.66 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.09 Pain Relevance 0

Paraffin-embedded tissues from dsRNA-treated and ssRNA-treated lungs were processed for immunohistochemical localization of Toll-like receptor 3 (TLR3) expression using a method previously described [33,39].

Localization (localization) of Toll-like receptor 3 in lungs

3) Confidence 0.62 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.09 Pain Relevance 0

Immunolocalization using goat anti-murine TLR3 Ab showed markedly increased expression of TLR3 localized to the surface airway epithelium of dsRNA-treated lungs as compared to ssRNA-treated controls at 72 h.

Localization (localized) of TLR3 in lungs

4) Confidence 0.62 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.26 Pain Relevance 0.08

Both TLR3 and TLR4 were found exclusively localized in vesicular structures inside microglia and not on the surface of the cells.

Neg (not) Localization (localized) of TLR3 in microglia

5) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.33 Pain Relevance 0.31

Interestingly. although TLR3 is critical for IFN-?

Localization (critical) of TLR3

6) Confidence 0.33 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.84 Pain Relevance 0

General Comments

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