INT183680

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Context Info
Confidence 0.71
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.69
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr3) signal transduction (Tlr3) endoplasmic reticulum (Tlr3)
RNA binding (Tlr3) intracellular (Tlr3) cytoplasm (Tlr3)
Anatomy Link Frequency
lungs 3
microglia 1
Tlr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 23 92.04 High High
Inflammatory response 12 90.80 High High
Inflammation 107 85.36 High High
chemokine 117 79.92 Quite High
agonist 27 55.68 Quite High
Inflammatory mediators 4 49.84 Quite Low
adenocard 1 42.16 Quite Low
anesthesia 5 39.36 Quite Low
cytokine 53 21.28 Low Low
ketamine 4 19.84 Low Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 92 94.40 High High
Pressure And Volume Under Development 30 92.16 High High
INFLAMMATION 99 90.40 High High
Autoimmune Disease 4 87.68 High High
Viral Infection 69 87.16 High High
Injury 39 85.80 High High
Bacterial Infection 2 85.72 High High
Coccidioides Infection 3 80.72 Quite High
Rabies Virus Infection 3 78.72 Quite High
Togavirus Infection 1 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunolocalization of TLR3
Localization (Immunolocalization) of TLR3
1) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.09 Pain Relevance 0
Paraffin-embedded tissues from dsRNA-treated and ssRNA-treated lungs were processed for immunohistochemical localization of Toll-like receptor 3 (TLR3) expression using a method previously described [33,39].
Localization (localization) of TLR3 in lungs
2) Confidence 0.66 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.09 Pain Relevance 0
Paraffin-embedded tissues from dsRNA-treated and ssRNA-treated lungs were processed for immunohistochemical localization of Toll-like receptor 3 (TLR3) expression using a method previously described [33,39].
Localization (localization) of Toll-like receptor 3 in lungs
3) Confidence 0.62 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.09 Pain Relevance 0
Immunolocalization using goat anti-murine TLR3 Ab showed markedly increased expression of TLR3 localized to the surface airway epithelium of dsRNA-treated lungs as compared to ssRNA-treated controls at 72 h.
Localization (localized) of TLR3 in lungs
4) Confidence 0.62 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.26 Pain Relevance 0.08
Both TLR3 and TLR4 were found exclusively localized in vesicular structures inside microglia and not on the surface of the cells.
Neg (not) Localization (localized) of TLR3 in microglia
5) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.33 Pain Relevance 0.31
Interestingly. although TLR3 is critical for IFN-?
Localization (critical) of TLR3
6) Confidence 0.33 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.84 Pain Relevance 0

General Comments

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