INT183681

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 28
Disease Relevance 16.25
Pain Relevance 4.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr3) signal transduction (Tlr3) endoplasmic reticulum (Tlr3)
RNA binding (Tlr3) intracellular (Tlr3) cytoplasm (Tlr3)
Anatomy Link Frequency
lung 6
poly 4
adult brain 1
fibroblasts 1
epithelial cells 1
Tlr3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 495 99.82 Very High Very High Very High
chemokine 109 99.78 Very High Very High Very High
Inflammatory response 114 99.58 Very High Very High Very High
Inflammation 628 99.44 Very High Very High Very High
rheumatoid arthritis 196 98.88 Very High Very High Very High
agonist 106 93.08 High High
tolerance 18 92.84 High High
ischemia 25 85.40 High High
Paracetamol 16 84.48 Quite High
Bile 11 82.48 Quite High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 53 99.84 Very High Very High Very High
Injury 246 99.66 Very High Very High Very High
Pneumonia 134 99.64 Very High Very High Very High
INFLAMMATION 675 99.38 Very High Very High Very High
Rheumatoid Arthritis 196 98.88 Very High Very High Very High
Cancer 145 98.72 Very High Very High Very High
Premature Birth 51 98.28 Very High Very High Very High
Peritonitis 2 98.10 Very High Very High Very High
Respiratory Syncytial Virus 13 97.08 Very High Very High Very High
Infection 234 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although we did not specifically measure TLR3 expression in the current study, review of our previously published microarray study indicates that TLR4 mRNA but not TLR3 mRNA is increased in mice mechanically ventilated with a tidal volume of 10 mL/kg as compared with control mice [9].
Positive_regulation (increased) of TLR3
1) Confidence 0.62 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.25 Pain Relevance 0.09
Here we investigate the effects of TLR3 activation on neurogenesis and fetal neocortical development and on neonatal and adult offspring behavior in a mouse model of gestational virus infection.
Spec (investigate) Positive_regulation (activation) of TLR3 associated with neurodegenerative disease and infection
2) Confidence 0.59 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.42 Pain Relevance 0
Indeed, activation of TLR3 is correlated with the production of neuroprotective, angiogenic and migratory factors by astrocytes [24].
Positive_regulation (activation) of TLR3 in astrocytes
3) Confidence 0.53 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 1.01 Pain Relevance 0.32
Role of TLR4 in ventilator-associated augmentation of TLR3-induced lung inflammation
Positive_regulation (augmentation) of TLR3 in lung associated with inflammation and pneumonia
4) Confidence 0.45 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.17 Pain Relevance 0.21
To assess the in vivo contribution of these PRRs in the poly(I:C)-induced IgG2c antibody response, Tlr3?
Positive_regulation (induced) of Tlr3 in poly
5) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.06 Pain Relevance 0
Another possibility is that the combination of mechanical ventilation and TLR3 activation causes cellular injury sufficient to release mitochondrial-derived, formylated proteins, which have recently been reported as a mechanism for neutrophil recruitment in the setting of sterile tissue injury [24].


Positive_regulation (activation) of TLR3 in neutrophil associated with injury
6) Confidence 0.41 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.49 Pain Relevance 0.10
These data show that mechanical ventilation does not require TLR4 to augment lung inflammation and injury associated with TLR3 activation.


Positive_regulation (activation) of TLR3 in lung associated with inflammation, injury and pneumonia
7) Confidence 0.41 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.65 Pain Relevance 0.24
In summary, mechanical ventilation with tidal volumes of 10 mL/kg augmented inflammation and lung permeability in response to TLR3 activation.
Positive_regulation (activation) of TLR3 in lung associated with inflammation
8) Confidence 0.41 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.55 Pain Relevance 0.08
The main findings of this study were: 1) mechanical ventilation augmented cytokine expression, PMN recruitment, and lung permeability, during TLR3 activation; and 2) maximal cytokine response, PMN recruitment, and vascular permeability induced by mechanical ventilation required the MyD88 adapter protein.
Positive_regulation (activation) of TLR3 in lung associated with cytokine
9) Confidence 0.41 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.58 Pain Relevance 0.37
In summary, this set of experiments yielded results similar to those observed in the first set of experiments in which mechanical ventilation augmented inflammation and lung permeability in the setting of TLR3 activation.
Positive_regulation (activation) of TLR3 in lung associated with inflammation
10) Confidence 0.41 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.49 Pain Relevance 0.18
A similar upregulation of TLR3 has previously been described in epithelial cells in vitro treated with Respiratory syncytial virus (RSV)[53].
Positive_regulation (upregulation) of TLR3 in Respiratory associated with respiratory syncytial virus
11) Confidence 0.41 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.56 Pain Relevance 0.10
The upregulation of TLR3 in dsRNA-exposed mouse airways suggests a positive feedback system in which epithelial cells exposed to dsRNA increase TLR3 expression on their cell surface.
Positive_regulation (upregulation) of TLR3 in epithelial cells
12) Confidence 0.41 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.53 Pain Relevance 0.10
C) administration leads to pronounced expression of proinflammatory cytokines through TLR3 activation (52).
Positive_regulation (activation) of TLR3 associated with cytokine
13) Confidence 0.39 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.49 Pain Relevance 0.22
The first set of experiments demonstrated that mechanical ventilation augments TLR3-induced cytokine production, PMN recruitment, and lung permeability via one or more MyD88-dependent pathways.
Positive_regulation (augments) of TLR3 in lung associated with cytokine
14) Confidence 0.39 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.29 Pain Relevance 0.21
The inhibitory effects of AM can also be nullified if mice or AMs are pretreated with poly I:C, which directly activate AMs and rDCs through toll-like receptors 3 (TLR3).
Positive_regulation (activate) of toll-like receptors 3 in poly
15) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2762542 Disease Relevance 1.21 Pain Relevance 0
The inhibitory effects of AM can also be nullified if mice or AMs are pretreated with poly I:C, which directly activate AMs and rDCs through toll-like receptors 3 (TLR3).
Positive_regulation (activate) of TLR3 in poly
16) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2762542 Disease Relevance 1.22 Pain Relevance 0
Induction of Toll-Like Receptor 3-Mediated Immunity during Gestation Inhibits Cortical Neurogenesis and Causes Behavioral Disturbances

Maternal infection during pregnancy with a wide range of RNA and DNA viruses is associated with increased risk for schizophrenia and autism in their offspring.

Positive_regulation (Induction) of Toll-Like Receptor 3 associated with autism, neurodegenerative disease, schizophrenia and infection
17) Confidence 0.34 Published 2010 Journal mBio Section Title Doc Link PMC2953007 Disease Relevance 0.49 Pain Relevance 0.12
It has recently been shown that microglia respond to poly I:C [a synthetic double-stranded (ds) RNA analog thought to be recognized by TLR3, [39]] by producing pro-inflammatory cytokines and chemokines [40], and microglial pro-inflammatory responses to dsRNA seem to be dependent on TLR3, as TLR3-deficient microglia have blunted innate cytokine responses in vitro and markedly reduced cell surface activation markers in brain after poly I:C stimulation (Town et al., submitted).
Positive_regulation (dependent) of TLR3 in microglia associated with chemokine, inflammatory response, inflammation and cytokine
18) Confidence 0.32 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.92 Pain Relevance 0.73
In contrast, TLR3-mediated signaling requires only the TRIF adaptor molecule, which is also recruited by TLR4 in association with the other adaptor, TRAM [77].
Positive_regulation (requires) of TLR3
19) Confidence 0.30 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0 Pain Relevance 0
Evidence suggests that TLR3 activation in trophoblasts may be a key mechanism to preterm birth outcome induced by infectious agents [60].
Positive_regulation (activation) of TLR3 associated with premature birth
20) Confidence 0.29 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 1.06 Pain Relevance 0.03

General Comments

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