INT183689

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 9.13
Pain Relevance 5.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
lung 9
liver 7
T cells 4
fibroblasts 3
plasma 2
Cxcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 401 100.00 Very High Very High Very High
chemokine 228 100.00 Very High Very High Very High
Inflammatory mediators 44 97.16 Very High Very High Very High
Inflammation 453 96.96 Very High Very High Very High
cva 16 94.08 High High
tolerance 60 92.00 High High
Inflammatory response 76 55.44 Quite High
Inflammatory stimuli 15 52.00 Quite High
ischemia 7 50.00 Quite Low
metalloproteinase 6 9.20 Low Low
Disease Link Frequency Relevance Heat
Adhesions 23 100.00 Very High Very High Very High
Cancer 85 99.68 Very High Very High Very High
Hepatotoxicity 25 99.36 Very High Very High Very High
Shock 6 98.48 Very High Very High Very High
Pneumonia 70 97.16 Very High Very High Very High
Lung Injury 110 96.88 Very High Very High Very High
INFLAMMATION 559 96.76 Very High Very High Very High
Apoptosis 61 96.16 Very High Very High Very High
Cervical Cancer 2 95.56 Very High Very High Very High
Infection 47 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
19- and 16-fold increase in KC and MCP-1 gene expression, respectively, over WT I/R tissues (data not shown; n=6; P<0.05).


Positive_regulation (increase) of Gene_expression (expression) of KC
1) Confidence 0.58 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.05 Pain Relevance 0.14
Its proinflammatory potential has been characterized in in vitro airway epithelial cells and fibroblasts where it induced the expression of various cytokines, chemokines, and adhesion molecules such as IL-6, IL-8, GRO?
Positive_regulation (induced) of Gene_expression (expression) of GRO in fibroblasts associated with chemokine, adhesions and cytokine
2) Confidence 0.49 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.53 Pain Relevance 0.17
Furthermore, expression of CXCR2 mRNA was similarly increased in parallel to the production of both CXCL1 and CXCL2/3 ligands and neutrophil sequestration during dsRNA-induced lung inflammation.
Positive_regulation (increased) of Gene_expression (production) of CXCL1 in lung associated with inflammation and pneumonia
3) Confidence 0.41 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.11 Pain Relevance 0.21
The finding of increased levels of KC/CXCL1 and MIP-2/CXCL2/3 associated with dsRNA-induced neutrophil sequestration and lung injury led us to evaluate the expression of CXCR2 mRNA in the lungs of these animals.
Positive_regulation (increased) of Gene_expression (levels) of KC/CXCL1 in lung associated with lung injury
4) Confidence 0.39 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.27 Pain Relevance 0.15
The results obtained in the acute group (24 hours following a single BCG instillation) indicate that with the exception of IL-6, KC, and MIP1?
Positive_regulation (following) of Gene_expression (exception) of KC associated with chemokine
5) Confidence 0.36 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.11 Pain Relevance 0.34
The mRNA data were confirmed by ELISA analysis (Figure 5A), which also showed that the protein levels of MIP-2, KC, IL-1?
Positive_regulation (showed) of Gene_expression (levels) of KC
6) Confidence 0.34 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.65 Pain Relevance 0.35
The main stimuli for KC production are IL-1, TNF-?
Positive_regulation (stimuli) of Gene_expression (production) of KC associated with chemokine
7) Confidence 0.32 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.35 Pain Relevance 0.59
Some representative examples include proinflammatory genes such as Interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) production, immune response genes such as Interleukin 11 (IL-11) and UPR genes such as activating transcription factor 4 (ATF 4), heat shock 70 kDa protein 8 (HSPA8) and X-box binding protein 1 (XBP1).
Positive_regulation (activating) of Gene_expression (production) of CXCL1 associated with chemokine and shock
8) Confidence 0.23 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.42 Pain Relevance 0.05
Stefanovic and Stefanovic reported that KC overexpression causes massive liver necrosis within 2 days and KC induces immediate expression of proinflammatory genes [21].
Positive_regulation (overexpression) of Gene_expression (overexpression) of KC in liver associated with chemokine and hepatotoxicity
9) Confidence 0.20 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.56 Pain Relevance 0.60
Its proinflammatory potential has been characterized in in vitro airway epithelial cells and fibroblasts where it induced the expression of various cytokines, chemokines, and adhesion molecules such as IL-6, IL-8, GRO?
Positive_regulation (induced) of in epithelial cells Gene_expression (expression) of GRO in fibroblasts associated with chemokine, adhesions and cytokine
10) Confidence 0.17 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.53 Pain Relevance 0.17
We observed that plasma levels of KC and IL-12p40 were elevated 6 h after the CpG-ODN challenge, whereas the levels of other mediators did not differ from those in the mice treated with the control ODN or PBS at the time point.
Positive_regulation (elevated) of Gene_expression (levels) of KC in plasma associated with chemokine
11) Confidence 0.15 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.54 Pain Relevance 0.36
Since we observed markedly elevated KC levels in BAL fluid as early as 6 h after the instillation of CpG-ODN, KC might be a key mediator that promoted neutrophil accumulation into the lung.
Positive_regulation (elevated) of Gene_expression (levels) of KC in lung associated with chemokine
12) Confidence 0.15 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.59 Pain Relevance 0.56
In addition, plasma KC levels were elevated at 24 h, suggesting that KC might contribute to further neutrophil recruitment into the lungs and liver.
Positive_regulation (elevated) of Gene_expression (levels) of KC in lungs associated with chemokine
13) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2761862 Disease Relevance 0.57 Pain Relevance 0.59
IFN-gamma induced overexpression of FasL in KC has been proposed as a mechanism of hepatic immunoregulation [17].
Positive_regulation (induced) of Gene_expression (overexpression) of KC
14) Confidence 0.09 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.21 Pain Relevance 0.16
IFN-gamma induced overexpression of FasL in KC has been proposed as a mechanism of hepatic immunoregulation [17].
Positive_regulation (overexpression) of Gene_expression (overexpression) of KC
15) Confidence 0.09 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.21 Pain Relevance 0.16
Donor Lewis hepatic KC replacement by recipient DA KC following liver transplantation results in increased FasL expression by KC in the liver allografts.
Positive_regulation (increased) of Gene_expression (expression) of KC in liver
16) Confidence 0.08 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.20 Pain Relevance 0.16
Since activated T cells express elevated level of Fas, we then determined the cytotoxicity of KC against alloreactive T cells (ATC).
Positive_regulation (elevated) of Gene_expression (express) of KC in T cells
17) Confidence 0.08 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.05 Pain Relevance 0
Since activated T cells express elevated level of Fas, we then determined the cytotoxicity of KC against alloreactive T cells (ATC).
Positive_regulation (activated) of Gene_expression (express) of KC in T cells
18) Confidence 0.08 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.05 Pain Relevance 0
KC FasL expression is increased following liver transplantation and associated with increased ability of KC lyses ATC.
Positive_regulation (increased) of Gene_expression (expression) of KC in liver
19) Confidence 0.08 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.23 Pain Relevance 0.07
, CXCL1, CXCL5/ENA78, CXCL8/IL8, CXCL9/MIG, CXCL10/IP10) were found to be overexpressed in the tumours while CCL15/MIP-1?
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CXCL1 associated with cancer
20) Confidence 0.07 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.30 Pain Relevance 0.05

General Comments

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