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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.26
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) signal transduction (Cxcr2) extracellular region (Cxcl1)
plasma membrane (Cxcr2) intracellular (Cxcr2) signal transducer activity (Cxcr2)
Anatomy Link Frequency
lung 1
neutrophil 1
Cxcr2 (Mus musculus)
Cxcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 57 100.00 Very High Very High Very High
Inflammation 139 95.96 Very High Very High Very High
Arthritis 4 65.28 Quite High
cytokine 48 58.12 Quite High
antagonist 3 9.68 Low Low
ischemia 26 6.28 Low Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 174 99.72 Very High Very High Very High
Lung Injury 40 98.32 Very High Very High Very High
INFLAMMATION 153 95.96 Very High Very High Very High
Crystal Associated Disease 75 92.72 High High
Acute-phase Reaction 1 88.28 High High
Disease 7 87.32 High High
Congenital Anomalies 1 78.68 Quite High
Peritonitis 7 78.00 Quite High
Targeted Disruption 17 75.36 Quite High
Hyperoxia 1 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these findings, we performed proof of principle studies in vivo using an antibody-mediated neutralization strategy to evaluate the direct role for CXCL1 and CXCL2/3 ligands and their interaction with CXCR2 during the pathogenesis of dsRNA-induced lung injury.
CXCR2 Binding (interaction) of CXCL1 in lung associated with lung injury
1) Confidence 0.33 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.14 Pain Relevance 0.17
CXCL1 binds to the chemokine receptors CXCR1 and CXCR2.
CXCR2 Binding (binds) of CXCL1 associated with chemokine
2) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.03 Pain Relevance 0.19
(CXCL1), bind to the receptor CXCR2 to promote neutrophil chemotaxis and can also affect angiogenesis.
CXCR2 Binding (bind) of CXCL1 in neutrophil
3) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 1.08 Pain Relevance 0.40

General Comments

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