INT18371

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Context Info
Confidence 0.60
First Reported 1989
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.49
Pain Relevance 4.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
plasma 2
dentate gyrus 2
ankle joint 2
neurons 2
adrenal medulla 2
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 26 100.00 Very High Very High Very High
medulla 6 100.00 Very High Very High Very High
Somatostatin 3 100.00 Very High Very High Very High
Dorsal horn 1 100.00 Very High Very High Very High
qutenza 9 99.82 Very High Very High Very High
fluoxetine 5 99.24 Very High Very High Very High
chung model 1 98.00 Very High Very High Very High
amygdala 4 97.60 Very High Very High Very High
agonist 2 96.08 Very High Very High Very High
allodynia 2 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 4 99.12 Very High Very High Very High
Arthritis 9 98.96 Very High Very High Very High
Injury 3 97.92 Very High Very High Very High
Neuropathic Pain 2 95.84 Very High Very High Very High
Stroke 4 93.20 High High
Nervous System Injury 1 86.00 High High
Hypoxia 1 83.28 Quite High
Middle Cerebral Artery Infarction 3 80.32 Quite High
Depression 4 75.00 Quite High
Pain 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with capsaicin did not affect the increased level of NPY-LI in the ankle joint of arthritic rats.
Neg (not) Regulation (affect) of Neg (not) Positive_regulation (increased) of NPY in ankle joint associated with qutenza and arthritis
1) Confidence 0.60 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7566511 Disease Relevance 0.79 Pain Relevance 0.76
Thus, the birth-related increases in TH, DBH, NPY, and ENK mRNA levels in the rat adrenal medulla are dependent on postnatal oxygenation.
Regulation (dependent) of Positive_regulation (increases) of NPY in adrenal medulla associated with medulla
2) Confidence 0.46 Published 1995 Journal Pediatr. Res. Section Abstract Doc Link 7651752 Disease Relevance 0.08 Pain Relevance 0.40
Based on experiments in the pithed guinea-pig, it is suggested that the PNS-induced increase of the plasma NPY-LI level is modulated by a prejunctional alpha 2-adrenoceptor mediated inhibitory control mechanism, since the alpha 2-agonist clonidine was found to reduce and the alpha 2-antagonist yohimbine to markedly enhance the PNS-induced increase in plasma NPY-LI, whereas the alpha 1-antagonist prazosin had no effect.
Regulation (modulated) of Positive_regulation (increase) of NPY in plasma associated with antagonist, agonist and clonidine
3) Confidence 0.45 Published 1989 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2557726 Disease Relevance 0 Pain Relevance 0.46
Results showed that animals with bilateral lesion have no significant change in NPY immunoreactivity versus control suggesting that the contralateral intact cortex is responsible for the increase of NPY-immunoreactive neurons detected after unilateral lesion.
Regulation (responsible) of Positive_regulation (increase) of NPY in cortex
4) Confidence 0.44 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8994222 Disease Relevance 0 Pain Relevance 0.08
However, in other brain regions, fluoxetine administration caused a differential effect on the induction of NPY-related genes in the two rat strains: in the CA region and dentate gyrus NPY mRNA expression was increased in the FSL, but decreased in the FRL.
Regulation (effect) of Positive_regulation (induction) of NPY-related in dentate gyrus associated with sprains and strains and fluoxetine
5) Confidence 0.43 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.54 Pain Relevance 0.88
We also monitored changes in the expression of neuropeptide Y (NPY) and the NPY Y1 receptor (Y1R) in the lumbar 4-5 dorsal root ganglia (DRG) and dorsal horn and found upregulation of NPY and downregulation of the Y1R in DRG neurons after injury.
Regulation (changes) of Positive_regulation (upregulation) of NPY in DRG associated with injury, dorsal horn and neuropeptide
6) Confidence 0.27 Published 2004 Journal Brain Res. Section Abstract Doc Link 15047027 Disease Relevance 0.55 Pain Relevance 0.56
We conclude that local cortical neurons are responsible for the increase in neuropeptide Y in the periinfarct region, that the cortical increase in tyrosine hydroxylase is not dependent on fast axonal transport, and that axonal transport of signals from the insular cortex to the amygdala is critical in mediating the amygdalar neuropeptide changes seen after stroke.
Regulation (responsible) of Positive_regulation (increase) of neuropeptide Y in neurons associated with stroke, neuropeptide and amygdala
7) Confidence 0.15 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9331169 Disease Relevance 0.53 Pain Relevance 0.64
The increased levels of neuropeptide Y mRNA and somatostatin mRNA in the grafts were due both to an increase in the number of labelled cells and to an increase in the cellular levels of each neuropeptide mRNA.
Regulation (due) of Positive_regulation (increased) of neuropeptide Y mRNA associated with somatostatin and neuropeptide
8) Confidence 0.12 Published 1990 Journal Neuroscience Section Abstract Doc Link 1972268 Disease Relevance 0 Pain Relevance 0.60

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