INT183722

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.63
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (HPN) plasma membrane (HPN) cytoplasm (HPN)
HPN (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 80.68 Quite High
ischemia 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
peptic ulcer disease 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 48 99.80 Very High Very High Very High
Thrombophilia 2 99.74 Very High Very High Very High
Prostate Cancer 55 97.36 Very High Very High Very High
Malignant Neoplastic Disease 7 95.56 Very High Very High Very High
Disseminated Intravascular Coagulation 19 92.28 High High
Disease 10 76.76 Quite High
Thrombosis 1 74.08 Quite High
Breast Cancer 2 67.52 Quite High
Coagulation Disorder 2 64.60 Quite High
Cystic Fibrosis 1 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HPN, which is overexpressed in primary cancer maintains high expression in the metastatic samples in our study.
Gene_expression (overexpressed) of HPN associated with cancer
1) Confidence 0.37 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.57 Pain Relevance 0
Molecular changes which may influence hypercoagulability include the expression of tissue factor (TF) as well as the proteases hepsin and cancer procoagulant by circulating tumour cells [4].
Gene_expression (expression) of hepsin associated with cancer and thrombophilia
2) Confidence 0.33 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1156959 Disease Relevance 1.00 Pain Relevance 0.08
Next to the nickel-transporters and urease/hydrogenase accessory proteins, H. pylori also expresses one or two small, very histidine-rich proteins (Hpn) which show strong binding to nickel (Gilbert et al. 1995; Ge et al. 2006).
Gene_expression (expresses) of Hpn
3) Confidence 0.20 Published 2007 Journal Biometals Section Body Doc Link PMC2798029 Disease Relevance 0.06 Pain Relevance 0
Finally, H. mustelae also expresses the histidine-rich Hpn protein (Gilbert et al. 1995), which is thought to function in nickel storage.


Gene_expression (expresses) of Hpn
4) Confidence 0.16 Published 2007 Journal Biometals Section Body Doc Link PMC2798029 Disease Relevance 0 Pain Relevance 0

General Comments

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