INT183753

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 8
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 13.13
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (HBM)
Anatomy Link Frequency
platelet 3
liver 2
spleen 2
blood 2
neutrophil 2
HBM (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 31 93.16 High High
Arthritis 55 92.84 High High
rheumatoid arthritis 54 92.64 High High
headache 12 90.04 High High
depression 9 86.96 High High
Angina 5 83.92 Quite High
Pain 28 77.08 Quite High
Inflammation 35 75.12 Quite High
alcohol 3 71.60 Quite High
fibrosis 8 67.84 Quite High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 20 99.76 Very High Very High Very High
Anaemia 101 98.98 Very High Very High Very High
Heart Disease 5 98.28 Very High Very High Very High
Gauchers Disease 223 97.68 Very High Very High Very High
Liver Disease 7 96.64 Very High Very High Very High
Congenital Anomalies 2 96.04 Very High Very High Very High
Adhesions 32 95.84 Very High Very High Very High
Malaria 2 95.72 Very High Very High Very High
Death 18 95.48 Very High Very High Very High
Chronic Hepatitis 8 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This does not mean that the other two components of the HBM are not effective in explaining health related behaviour, only that they did not show to be for the prisoner population in our study.
Neg (not) Regulation (effective) of HBM
1) Confidence 0.39 Published 2008 Journal Harm Reduct J Section Body Doc Link PMC2443130 Disease Relevance 0.50 Pain Relevance 0
For the 78 included patients, 45 (57%) had a hemoglobin value less than 110 g/L.
Regulation (value) of hemoglobin
2) Confidence 0.11 Published 2005 Journal BMC Pediatr Section Body Doc Link PMC1322220 Disease Relevance 0.71 Pain Relevance 0
The changes in hemoglobin and hematocrit were reflective of changes in resting plasma volume from pre- to post-supplementation of +4.7 ± 4.7% and +0.5 ± 2.1% in the creatine and placebo groups, respectively (P = N.S.).
Regulation (changes) of hemoglobin in plasma
3) Confidence 0.07 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2909923 Disease Relevance 0 Pain Relevance 0.03
There were no significant changes in hemoglobin levels or platelets counts.
Neg (no) Regulation (changes) of hemoglobin in platelets
4) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 0.35 Pain Relevance 0.03
No significant differences were noted among the three groups in terms of changes in liver and spleen volumes and hemoglobin levels after 6 months of treatment (Table 1).
Regulation (changes) of hemoglobin in liver
5) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 0.13 Pain Relevance 0
All patients in the ICS group received the processed autologous blood; further allogenic transfusion in the perioperative period was dependent on the clinical assessment made by the anesthetist and the surgeon, on the basis of patient's age, comorbidities, preoperative hemoglobin, and blood loss.
Regulation (dependent) of hemoglobin in blood associated with pressure volume 2 under development
6) Confidence 0.05 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2938542 Disease Relevance 0.17 Pain Relevance 0
The effect of surgical intervention on hemoglobin, hematocrit and RBC values was assessed by re-analyzing the data after excluding all post-surgical lab values from the original dataset.
Regulation (values) of hemoglobin
7) Confidence 0.05 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.30 Pain Relevance 0.12
Bonferroni post-test performed on this reduced dataset still demonstrates the same significant decrease in hemoglobin, hematocrit and RBC values from pre-18F-FLT to immediately post-18F-FLT times but without subsequent lowering at later time points.
Regulation (values) of hemoglobin
8) Confidence 0.05 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.40 Pain Relevance 0.19
Hemoglobin and hematocrit were not affected with the single dose administered.


Neg (not) Regulation (affected) of Hemoglobin
9) Confidence 0.04 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1164417 Disease Relevance 0.63 Pain Relevance 0.23
-reductase inhibitors for any of the above mentioned markers with the conclusion that suppression of serum DHT induced by finasteride during 12 months did not adversely affect bone turnover, serum lipoproteins, or hemoglobin.
Neg (not) Regulation (affect) of hemoglobin
10) Confidence 0.03 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710385 Disease Relevance 0.48 Pain Relevance 0.14
There were no significant changes in liver, spleen volume, or hemoglobin level.
Neg (no) Regulation (changes) of hemoglobin in spleen
11) Confidence 0.03 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 0.09 Pain Relevance 0
No significant differences were noted among the three groups in terms of changes in liver and spleen volumes and hemoglobin levels after 6 months of treatment (Table 1).
Regulation (changes) of hemoglobin in spleen
12) Confidence 0.02 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 0.13 Pain Relevance 0
In the studies, we could not verify the increase in RBC survival duration as neither reticulocyte counts nor hemoglobin levels were not changed significantly.
Neg (not) Regulation (changed) of hemoglobin in reticulocyte
13) Confidence 0.01 Published 2005 Journal BMC Blood Disord Section Body Doc Link PMC1198219 Disease Relevance 0.47 Pain Relevance 0
Ustekinumab showed no effect on glucose, hemoglobin A1c, neutrophil counts, or D-dimer levels.
Neg (no) Regulation (effect) of hemoglobin in neutrophil
14) Confidence 0.01 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.68 Pain Relevance 0.12
In a large international cohort of children with GD type 1 on ERT, the longitudinal data supports the normalization of most clinical parameters including mean height, hemoglobin values and mean bone mineral density z scores.40 Several consensus statements for treatment and monitoring of children with GD, include regular assessments, and individualized dose adjustments based on clinical response.41,42 Although a lower maintenance dose of 30–35 IU/kg/month may be effective in most pediatric patients, more severely affected ones, especially L444P/L444P homozygotes, may require a higher maintenance dosage.43 In addition to clinical parameters, the follow up in this age group should also include evaluation of psychosocial, functional status and quality-of-life assessments.44
Regulation (values) of hemoglobin associated with gauchers disease
15) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 0.43 Pain Relevance 0
There were no significant changes in liver, spleen volume, or hemoglobin level.
Neg (no) Regulation (changes) of hemoglobin in liver
16) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 0.09 Pain Relevance 0
However, randomized controlled trials targeting different hemoglobin (Hb) levels in hemodialysis patients with cardiac disease show conflicting results.
Regulation (targeting) of hemoglobin associated with heart disease
17) Confidence 0.01 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.87 Pain Relevance 0
GLM treatment significantly improved anemia compared with placebo.40 Associations between the change in hemoglobin (Hb) levels and that in the SF-36 vitality scale or that in physical function, as measured using the HAQ disability index, were assessed through week 24.
Regulation (change) of hemoglobin associated with anaemia
18) Confidence 0.01 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 2.04 Pain Relevance 0.76
Expression levels of hemoglobin related genes are modified by selection for tameness
Regulation (modified) of hemoglobin
19) Confidence 0.01 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0
For example, deleterious mutations affecting hemoglobin and other red blood cell proteins are common in many human populations due to a heterozygote advantage in malaria epidemic environments.
Regulation (affecting) of hemoglobin in red blood cell associated with malaria
20) Confidence 0.01 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134963 Disease Relevance 0.68 Pain Relevance 0.07

General Comments

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