INT183755

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.91
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPC)
Anatomy Link Frequency
plasma 2
fundus 1
GYPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 99.48 Very High Very High Very High
Cholecystokinin 372 99.44 Very High Very High Very High
cytokine 8 98.96 Very High Very High Very High
Opioid 10 85.92 High High
Inflammatory mediators 4 48.32 Quite Low
antagonist 28 5.00 Very Low Very Low Very Low
Versed 12 5.00 Very Low Very Low Very Low
Morphine 12 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastric Motility Disorder 210 100.00 Very High Very High Very High
Critical Illness 230 99.88 Very High Very High Very High
INFLAMMATION 6 99.48 Very High Very High Very High
Injury 54 98.60 Very High Very High Very High
Hypoxia 1 97.80 Very High Very High Very High
Brain Injury 28 94.56 High High
Congenital Anomalies 2 93.12 High High
Burns 22 90.48 High High
Anaemia 9 81.68 Quite High
Sepsis 43 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thermal injury has been shown to relax the fundus, reduce antral motility, and slow GE due to increases in both sympathetic and opiatergic neural activity and due to release of systemic inflammatory cytokines [2-6,28,29].
Localization (release) of GE in fundus associated with inflammation, injury, gastric motility disorder and cytokine
1) Confidence 0.56 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 2.10 Pain Relevance 0.19
Analysis of breath samples and GE
Localization (Analysis) of GE associated with gastric motility disorder
2) Confidence 0.56 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 0.23 Pain Relevance 0
Together, these findings suggest that, in critically ill patients, there is a complex interaction between GE, intestinal nutrients, and hormonal release.
Localization (release) of GE associated with critical illness
3) Confidence 0.07 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.18 Pain Relevance 0.19
Given the relatively small gastric nutrient load and high frequency of delayed GE (64%), the existence of the relationship between GE and the hormonal release may simply reflect the level of duodenal nutrient stimulation.
Localization (release) of GE
4) Confidence 0.07 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.30 Pain Relevance 0.20
The major observations are that, during critical illness, (a) GE was inversely related to both fasting and postprandial plasma CCK and PYY concentrations but (b) the postprandial increases in plasma CCK and PYY were also directly related to GE.
Localization (related) of GE in plasma associated with critical illness and cholecystokinin
5) Confidence 0.07 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.42 Pain Relevance 0.46
The major observations are that, during critical illness, (a) GE was inversely related to both fasting and postprandial plasma CCK and PYY concentrations but (b) the postprandial increases in plasma CCK and PYY were also directly related to GE.
Localization (related) of GE in plasma associated with critical illness and cholecystokinin
6) Confidence 0.07 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.43 Pain Relevance 0.38
Erythropoietin (EPO) is a sialoglycoprotein hormone secreted primarily by the mature kidneys in response to tissue hypoxia and/or red cell mass decrease.
Localization (secreted) of sialoglycoprotein associated with hypoxia
7) Confidence 0.04 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1164417 Disease Relevance 0.26 Pain Relevance 0

General Comments

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