INT183781

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 8.97
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, INS) extracellular region (IL6, INS) small molecule metabolic process (INS)
aging (IL6) carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 2
heart 1
IL6 (Homo sapiens)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 35 98.12 Very High Very High Very High
Inflammation 239 97.12 Very High Very High Very High
cytokine 109 96.72 Very High Very High Very High
Arthritis 40 91.56 High High
chemokine 67 91.12 High High
antidepressant 41 90.68 High High
tolerance 17 88.20 High High
metalloproteinase 8 87.36 High High
Inflammatory marker 7 82.64 Quite High
Inflammatory response 29 67.24 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 136 100.00 Very High Very High Very High
Obesity 81 100.00 Very High Very High Very High
Insulin Resistance 61 100.00 Very High Very High Very High
Myocardial Infarction 46 100.00 Very High Very High Very High
Hyperglycemia 5 100.00 Very High Very High Very High
Stress 25 98.24 Very High Very High Very High
Rheumatoid Arthritis 35 98.12 Very High Very High Very High
Increased Venous Pressure Under Development 46 97.44 Very High Very High Very High
INFLAMMATION 298 97.12 Very High Very High Very High
Apnoea 89 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
concentrations in depressed and diabetic patients and IL-6 represents the higher association with obesity and insulin resistance [42, 43].
IL-6 Binding (association) of insulin associated with diabetes mellitus, obesity and insulin resistance
1) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2872762 Disease Relevance 0.91 Pain Relevance 0.33
Substantial experimental evidence and cross-sectional data suggest that IL-6 is associated with hyperglycemia, insulin resistance, and overt type 2 diabetes [33,34].
IL-6 Binding (associated) of insulin associated with hyperglycemia, diabetes mellitus and insulin resistance
2) Confidence 0.13 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 1.71 Pain Relevance 0.16
and IL-6, associated with obesity and type 2 diabetes, might interfere with insulin action by suppressing insulin signal transduction, which in turn might promote inflammation.
IL-6 Binding (interfere) of insulin associated with inflammation, diabetes mellitus and obesity
3) Confidence 0.08 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.55 Pain Relevance 0.38
Circulation of IL-6 in plasma is at high concentrations and is associated with insulin resistance in men and in obese or hyperandrogenic women [27].
IL-6 Binding (associated) of insulin in plasma associated with obesity and insulin resistance
4) Confidence 0.04 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 0.98 Pain Relevance 0.16
The IL-6 -174G > C common functional gene variant has consistently been associated with increased plasma IL-6, insulin resistance, and increased cardiovascular risk [130].
IL-6 Binding (associated) of insulin in plasma associated with insulin resistance
5) Confidence 0.02 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 1.45 Pain Relevance 0.15
and IL-6 has been associated with heart failure as well as with insulin resistance, dys-lipidemia, and obesity [36,43].
IL-6 Binding (associated) of insulin in heart associated with obesity, insulin resistance and myocardial infarction
6) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 2.31 Pain Relevance 0.68

General Comments

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