INT183789

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.87
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
adipocytes 4
ovary 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 81 96.40 Very High Very High Very High
Inflammation 133 96.00 Very High Very High Very High
antagonist 2 94.04 High High
tolerance 3 57.04 Quite High
Inflammatory response 19 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
Inflammatory stimuli 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 151 99.76 Very High Very High Very High
Insulin Resistance 21 99.48 Very High Very High Very High
Diabetes Mellitus 220 99.20 Very High Very High Very High
INFLAMMATION 174 96.00 Very High Very High Very High
Weight Gain 14 88.36 High High
Pressure And Volume Under Development 2 82.76 Quite High
Hypoglycemia 77 72.56 Quite High
Apoptosis 6 71.56 Quite High
Disease 69 69.32 Quite High
Hyperglycemia 6 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biphasic insulin aspart versus NPH or glargine in type 2 diabetes
Positive_regulation (versus) of Phosphorylation (aspart) of Biphasic insulin associated with diabetes mellitus
1) Confidence 0.50 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.72 Pain Relevance 0
causes an inhibition of auto-phosphorylation of tyrosine residues of the insulin receptor (IR) and an induction of serine phosphorylation of insulin receptor substrate-1, which in turn causes serine phosphorylation of the IR in adipocytes and inhibits tyrosine phosphorylation [74].
Positive_regulation (induction) of Phosphorylation (phosphorylation) of insulin in adipocytes associated with obesity
2) Confidence 0.15 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.50 Pain Relevance 0.26
and is involved in insulin resistance in adipocytes through an increase in insulin receptor substrate (IRS)-1 serine phosphorylation and/or a decrease in its expression (7–9).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of insulin in adipocytes associated with obesity and insulin resistance
3) Confidence 0.05 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.71 Pain Relevance 0.38
Experiments on rat tissues suggest that selenate treatment induces increased phosphorylation of the insulin-receptor beta subunit and of other downstream proteins of the insulin-signaling pathway [3].
Positive_regulation (increased) of Phosphorylation (phosphorylation) of insulin
4) Confidence 0.04 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2850339 Disease Relevance 0.37 Pain Relevance 0
Experiments on rat tissues suggest that selenate treatment induces increased phosphorylation of the insulin-receptor beta subunit and of other downstream proteins of the insulin-signaling pathway [3].
Positive_regulation (induces) of Phosphorylation (phosphorylation) of insulin
5) Confidence 0.04 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2850339 Disease Relevance 0.43 Pain Relevance 0
The specific PTP1B inhibitor used in this work has been seen to stimulate insulin signaling and Akt phosphorylation in ovary cells (35), but no references regarding effects on endothelial cells have been found.
Positive_regulation (stimulate) of Phosphorylation (phosphorylation) of insulin in ovary
6) Confidence 0.03 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.14 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox