INT183789

Context Info Confidence 0.50 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 4.87 Pain Relevance 0.64

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS) carbohydrate metabolic process (INS) cell-cell signaling (INS)

Anatomy Link Frequency adipocytes 4 ovary 2 INS (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 81 96.40 Inflammation 133 96.00 antagonist 2 94.04 tolerance 3 57.04 Inflammatory response 19 5.00 alcohol 12 5.00 Inflammatory mediators 10 5.00 Inflammatory stimuli 6 5.00 cINOD 4 5.00 chemokine 4 5.00

Disease Link Frequency Relevance Heat Obesity 151 99.76 Insulin Resistance 21 99.48 Diabetes Mellitus 220 99.20 INFLAMMATION 174 96.00 Weight Gain 14 88.36 Pressure And Volume Under Development 2 82.76 Hypoglycemia 77 72.56 Apoptosis 6 71.56 Disease 69 69.32 Hyperglycemia 6 67.52

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Biphasic insulin aspart versus NPH or glargine in type 2 diabetes

Positive_regulation (versus) of Phosphorylation (aspart) of Biphasic insulin associated with diabetes mellitus

1) Confidence 0.50 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.72 Pain Relevance 0

causes an inhibition of auto-phosphorylation of tyrosine residues of the insulin receptor (IR) and an induction of serine phosphorylation of insulin receptor substrate-1, which in turn causes serine phosphorylation of the IR in adipocytes and inhibits tyrosine phosphorylation [74].

Positive_regulation (induction) of Phosphorylation (phosphorylation) of insulin in adipocytes associated with obesity

2) Confidence 0.15 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.50 Pain Relevance 0.26

and is involved in insulin resistance in adipocytes through an increase in insulin receptor substrate (IRS)-1 serine phosphorylation and/or a decrease in its expression (7–9).

Positive_regulation (increase) of Phosphorylation (phosphorylation) of insulin in adipocytes associated with obesity and insulin resistance

3) Confidence 0.05 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.71 Pain Relevance 0.38

Experiments on rat tissues suggest that selenate treatment induces increased phosphorylation of the insulin-receptor beta subunit and of other downstream proteins of the insulin-signaling pathway [3].

Positive_regulation (increased) of Phosphorylation (phosphorylation) of insulin

4) Confidence 0.04 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2850339 Disease Relevance 0.37 Pain Relevance 0

Experiments on rat tissues suggest that selenate treatment induces increased phosphorylation of the insulin-receptor beta subunit and of other downstream proteins of the insulin-signaling pathway [3].

Positive_regulation (induces) of Phosphorylation (phosphorylation) of insulin

5) Confidence 0.04 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2850339 Disease Relevance 0.43 Pain Relevance 0

The specific PTP1B inhibitor used in this work has been seen to stimulate insulin signaling and Akt phosphorylation in ovary cells (35), but no references regarding effects on endothelial cells have been found.

Positive_regulation (stimulate) of Phosphorylation (phosphorylation) of insulin in ovary

6) Confidence 0.03 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.14 Pain Relevance 0

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