INT183789
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Biphasic insulin aspart versus NPH or glargine in type 2 diabetes | |||||||||||||||
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causes an inhibition of auto-phosphorylation of tyrosine residues of the insulin receptor (IR) and an induction of serine phosphorylation of insulin receptor substrate-1, which in turn causes serine phosphorylation of the IR in adipocytes and inhibits tyrosine phosphorylation [74]. | |||||||||||||||
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and is involved in insulin resistance in adipocytes through an increase in insulin receptor substrate (IRS)-1 serine phosphorylation and/or a decrease in its expression (79). | |||||||||||||||
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Experiments on rat tissues suggest that selenate treatment induces increased phosphorylation of the insulin-receptor beta subunit and of other downstream proteins of the insulin-signaling pathway [3]. | |||||||||||||||
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Experiments on rat tissues suggest that selenate treatment induces increased phosphorylation of the insulin-receptor beta subunit and of other downstream proteins of the insulin-signaling pathway [3]. | |||||||||||||||
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The specific PTP1B inhibitor used in this work has been seen to stimulate insulin signaling and Akt phosphorylation in ovary cells (35), but no references regarding effects on endothelial cells have been found. | |||||||||||||||
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General Comments
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