INT183810

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.15
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
Anatomy Link Frequency
THP-1 2
fibroblasts 2
neutrophils 2
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 227 100.00 Very High Very High Very High
alcohol 18 97.44 Very High Very High Very High
ischemia 25 95.36 Very High Very High Very High
Inflammatory stimuli 3 89.44 High High
Inflammation 101 82.68 Quite High
rheumatoid arthritis 152 81.60 Quite High
Angina 39 78.00 Quite High
spinal inflammation 30 64.64 Quite High
cytokine 15 63.24 Quite High
Osteoarthritis 16 48.16 Quite Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 49 99.84 Very High Very High Very High
Acute Coronary Syndrome 74 99.04 Very High Very High Very High
Disease 22 98.52 Very High Very High Very High
Nicotine Addiction 22 98.00 Very High Very High Very High
Hypertension 4 96.72 Very High Very High Very High
Cv Unclassified Under Development 15 95.36 Very High Very High Very High
Necrosis 32 94.64 High High
Rupture 19 92.20 High High
Targeted Disruption 2 90.48 High High
INFLAMMATION 109 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the surface expression of CD44 is required for the activation of MMP-9.
Positive_regulation (required) of Positive_regulation (activation) of MMP-9
1) Confidence 0.52 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.05 Pain Relevance 0
Experiments where MonoMac 6 cells were pre exposed to AA for increasing periods of time (Fig. 2B) showed that the system delivering MMP-9 to the medium was activated already after 1 h incubation and increased for at least 6 h.
Positive_regulation (increased) of Positive_regulation (activated) of MMP-9
2) Confidence 0.43 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.06 Pain Relevance 0.03
Experiments where MonoMac 6 cells were pre exposed to AA for increasing periods of time (Fig. 2B) showed that the system delivering MMP-9 to the medium was activated already after 1 h incubation and increased for at least 6 h.
Positive_regulation (activated) of Positive_regulation (activated) of MMP-9
3) Confidence 0.43 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.06 Pain Relevance 0.03
While there is a number of experimental or cross-sectional studies in selected populations that associates elevated levels of MMP-9 to CAD risk factors before onset of disease e.g. smoking [19], alcohol [20], and hypertension [21], [22], little is still known about the distribution of MMP-9 in the general population.
Positive_regulation (elevated) of Positive_regulation (levels) of MMP-9 associated with nicotine addiction, coronary artery disease, hypertension, disease and alcohol
4) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 1.46 Pain Relevance 0.27
We observed that pretreatment of PC3/OPN cells with a neutralizing antibody against CD44 clearly blocked the OPN-induced activation of MMP-9 (lane 5).
Positive_regulation (induced) of Positive_regulation (activation) of MMP-9
5) Confidence 0.38 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.12 Pain Relevance 0
The demonstrated increase in IL-17A mRNA is associated with an increased absolute number of MMP-9 expressing BAL neutrophils at the same time point.
Positive_regulation (increased) of Positive_regulation (number) of MMP-9 in neutrophils associated with metalloproteinase
6) Confidence 0.26 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0.16 Pain Relevance 0.25
Significantly elevated release and activation of MMP-9 and/or MMP-2 were seen in the co-culture of human monocytes/THP-1 cells and fibroblasts compared with cultures of the cells alone.
Positive_regulation (elevated) of Positive_regulation (activation) of MMP-9 in fibroblasts associated with metalloproteinase
7) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257431 Disease Relevance 0.77 Pain Relevance 0.72
The co-culture of undifferentiated THP-1 cells and fibroblasts showed a significantly elevated level of release and activation of MMP-2 and particularly MMP-9 compared with the cultures of THP-1 cells or fibroblasts alone (Fig. 5a).
Positive_regulation (elevated) of Positive_regulation (activation) of MMP-9 in THP-1 associated with metalloproteinase
8) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.28 Pain Relevance 0.71
Briefly, preliminary studies suggest that MMP-9 may be of value in evaluating ACS patients but additional investigations will be necessary for better acceptance of MMP-9 commercialization and clinical application.


Spec (investigations) Positive_regulation (necessary) of Positive_regulation (acceptance) of MMP-9 associated with acute coronary syndrome
9) Confidence 0.07 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.90 Pain Relevance 0.27
Increased expression and activity of MMP-9 was shown to be ET-1 mediated and also present in a small cohort of humans exposed to diesel exhausts [118].
Positive_regulation (Increased) of Positive_regulation (activity) of MMP-9 associated with metalloproteinase
10) Confidence 0.05 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.30 Pain Relevance 0.18

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