INT183814

Context Info Confidence 0.69 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.04 Pain Relevance 0.29

cytosol (HPRT1) small molecule metabolic process (HPRT1) transferase activity, transferring glycosyl groups (HPRT1) cytoplasm (HPRT1)

Anatomy Link Frequency muscle 1 HPRT1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 51 97.52 cytokine 17 93.68 metalloproteinase 22 5.00 anesthesia 4 5.00 agonist 4 5.00 ketamine 2 5.00 Inflammatory stimuli 2 5.00 Inflammatory mediators 2 5.00 Pain 1 5.00 Morphine 1 5.00

Disease Link Frequency Relevance Heat Necrosis 2 99.04 Cancer 2 98.68 INFLAMMATION 53 97.52 Lung Injury 16 90.24 Hyperinsulinism 2 88.76 Familial Dysautonomia 75 50.00 Atelectasis 2 25.24 Pneumonia 11 5.00 Targeted Disruption 10 5.00 Cognitive Disorder 7 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

mRNA and hypoxanthine phosphoribosyltransferase (HPRT) mRNA expression was quantified using QRTPCR.

Transcription (expression) of HPRT

1) Confidence 0.69 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2873469 Disease Relevance 0.48 Pain Relevance 0.14

mRNA and hypoxanthine phosphoribosyltransferase (HPRT) mRNA expression was quantified using QRTPCR.

Transcription (expression) of hypoxanthine phosphoribosyltransferase

2) Confidence 0.52 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2873469 Disease Relevance 0.48 Pain Relevance 0.14

HPRT1 mRNA served as the reference transcript.

Transcription (served) of HPRT1

3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0 Pain Relevance 0

For normalization HPRT mRNA was amplified using HPRT-F (5?

Transcription (amplified) of HPRT

4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0 Pain Relevance 0

The HPRT1 transcript was selected as the reference gene on an empirical basis—HPRT1 expression in these men (1863±111 arbitrary units, mean±SEM) and women (1881±138 arbitrary units) was similar according to the microarray data (this choice does not necessarily mean that HPRT1 expression always is constant in muscle).

Transcription (selected) of HPRT1 in muscle

5) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.09 Pain Relevance 0

The expression of transcripts for IL-17 mRNA was normalized to the expression of HPRT transcripts and shown as percent of the house-keeping gene (% HPRT).

Transcription (expression) of HPRT

6) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0 Pain Relevance 0

General Comments

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