INT18385

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Context Info
Confidence 0.75
First Reported 1981
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.05
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
hippocampus 3
blood 1
cleavage 1
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 35 100.00 Very High Very High Very High
Hippocampus 12 99.68 Very High Very High Very High
Enkephalin 4 88.00 High High
anesthesia 1 81.08 Quite High
Disease Link Frequency Relevance Heat
Duodenal Ulcer 2 51.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The degradation of somatostatin by synaptic membrane of rat hippocampus is initiated by endopeptidase-24.11.
Protein_catabolism (degradation) of somatostatin in hippocampus associated with somatostatin and hippocampus
1) Confidence 0.75 Published 1990 Journal Peptides Section Title Doc Link 1972574 Disease Relevance 0 Pain Relevance 0.35
Thus, it can be concluded that endopeptidase-24.11 plays a major role in the initial stage of somatostatin degradation in rat hippocampus.
Protein_catabolism (degradation) of somatostatin in hippocampus associated with somatostatin and hippocampus
2) Confidence 0.75 Published 1990 Journal Peptides Section Abstract Doc Link 1972574 Disease Relevance 0 Pain Relevance 0.44
Somatostatin was degraded by the synaptic membrane from rat hippocampus.
Protein_catabolism (degraded) of Somatostatin in hippocampus associated with somatostatin and hippocampus
3) Confidence 0.75 Published 1990 Journal Peptides Section Abstract Doc Link 1972574 Disease Relevance 0 Pain Relevance 0.20
Because blood levels of somatostatin fell, and only trivial amounts of the peptide were found in the stomach lumen after cysteamine administration, it appears likely that this agent acts at the cellular level to cause breakdown of preformed somatostatin and/or to acutely reduce its synthesis.
Protein_catabolism (breakdown) of somatostatin in blood associated with somatostatin
4) Confidence 0.66 Published 1981 Journal Endocrinology Section Abstract Doc Link 6118261 Disease Relevance 0.05 Pain Relevance 0.46
The accumulation of the major cleavage products, as well as the initial cleavage of somatostatin, was strongly inhibited by metal chelators and also by specific inhibitors of endopeptidase-24.11 (EC 3.4.24.11), phosphoramidon and thiorphan.
Protein_catabolism (cleavage) of somatostatin in cleavage associated with somatostatin
5) Confidence 0.49 Published 1990 Journal Peptides Section Abstract Doc Link 1972574 Disease Relevance 0 Pain Relevance 0.41

General Comments

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