INT183852

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.63
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (CAV1, RHOC) cytoplasm (CAV1, RHOC) cytosol (CAV1, RHOC)
plasma membrane (CAV1, RHOC) endosome (CAV1) mitochondrion (CAV1)
Anatomy Link Frequency
arm 2
CAV1 (Homo sapiens)
RHOC (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 102 96.96 Very High Very High Very High
Cancer 62 86.96 High High
Pancreatic Cancer 14 57.88 Quite High
Clostridium Infection 2 55.36 Quite High
Metastasis 46 49.24 Quite Low
Carcinoma 2 9.84 Low Low
Pancreatitis 4 5.00 Very Low Very Low Very Low
Inflammatory Breast Neoplasms 4 5.00 Very Low Very Low Very Low
Renal Cancer 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data further suggest that activation of RhoC GTPase is regulated by cav-1 and that RhoC signals through the p38 arm of the MAPK pathway to induce cellular migration.


cav-1 Regulation (regulated) of Positive_regulation (activation) of RhoC in arm
1) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.37 Pain Relevance 0
Compared with the controls, transient ectopic re-expression of cav-1 decreased levels of active RhoC by 6-fold without effecting total RhoC protein levels, suggesting regulation of RhoC activation by cav-1.
cav-1 Regulation (regulation) of Positive_regulation (activation) of RhoC
2) Confidence 0.25 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.26 Pain Relevance 0

General Comments

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