INT183860

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (RHOC, CAV1) cytoplasm (RHOC, CAV1) cytosol (RHOC, CAV1)
plasma membrane (RHOC, CAV1) endosome (CAV1) mitochondrion (CAV1)
Anatomy Link Frequency
HPAF-II 1
RHOC (Homo sapiens)
CAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 44.88 Quite Low
Chronic pancreatitis 6 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 153 93.52 High High
Pancreatic Cancer 21 50.00 Quite Low
Inflammatory Breast Neoplasms 6 44.88 Quite Low
Clostridium Infection 3 24.72 Low Low
Cancer 93 5.00 Very Low Very Low Very Low
Metastasis 69 5.00 Very Low Very Low Very Low
Pancreatitis 6 5.00 Very Low Very Low Very Low
Renal Cancer 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 4A are the results of immunoprecipitation assays using either a polyclonal or monoclonal antibody specific for cav-1 followed by immunoblotting for RhoC.
RhoC Binding (immunoblotting) of cav-1
1) Confidence 0.34 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.16 Pain Relevance 0
Furthermore, interaction of cav-1 and RhoC may result in decreased RhoC activation, limiting cell migration and invasion.


RhoC Binding (interaction) of cav-1
2) Confidence 0.33 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.09 Pain Relevance 0
Unexpectedly, the association between cav-1 and RhoC was restored in the HPAF-II/dnRhoC cell line suggesting that inhibition of RhoC activity leads to re-expression of cav-1 protein.
RhoC Binding (association) of cav-1 in HPAF-II
3) Confidence 0.33 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.14 Pain Relevance 0

General Comments

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