INT183874

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RHOC) signal transduction (RHOC) plasma membrane (RHOC)
nucleus (RHOC) intracellular (RHOC) GTPase activity (RHOC)
RHOC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 48.08 Quite Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 102 96.72 Very High Very High Very High
Pancreatic Cancer 14 50.00 Quite Low
Inflammatory Breast Neoplasms 4 48.08 Quite Low
Cancer 62 5.00 Very Low Very Low Very Low
Metastasis 46 5.00 Very Low Very Low Very Low
Pancreatitis 4 5.00 Very Low Very Low Very Low
Renal Cancer 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High cav-1 protein expression leads to inhibition of RhoC activation while inhibition of RhoC activity leads to partial re-expression of cav-1.
Negative_regulation (inhibition) of Positive_regulation (activation) of RhoC
1) Confidence 0.35 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.08 Pain Relevance 0
Furthermore, interaction of cav-1 and RhoC may result in decreased RhoC activation, limiting cell migration and invasion.


Negative_regulation (decreased) of Positive_regulation (activation) of RhoC
2) Confidence 0.35 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.10 Pain Relevance 0

General Comments

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