INT183876

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.94
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDC42) plasma membrane (CDC42) cytoskeleton (CDC42)
intracellular (CDC42) GTPase activity (CDC42) cell division (CDC42)
CDC42 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 96.52 Very High Very High Very High
tolerance 13 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 79 99.52 Very High Very High Very High
Clostridium Infection 2 98.50 Very High Very High Very High
Metastasis 46 98.20 Very High Very High Very High
Pancreatitis 4 96.52 Very High Very High Very High
Cancer 62 92.20 High High
Adenocarcinoma 102 91.92 High High
Pancreatic Cancer 14 78.88 Quite High
Insulin Resistance 35 50.00 Quite Low
Renal Cancer 2 20.80 Low Low
Skin Cancer 2 18.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, our new analysis procedure subsequently identified CDC42 and PTBP1 as being equally targeted by both up- and down-regulated miRNAs (Additional file 2); thus, CDC42 and PTBP1 should not be altered in vivo by diabetes (as we demonstrated by western blotting prior to developing our ranking metric).


Neg (not) Regulation (altered) of CDC42 associated with diabetes mellitus
1) Confidence 0.30 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.28 Pain Relevance 0
C3 exotransferase is a toxin derived from Clostridium botulinum and is effective at inhibiting RhoA, -B and -C activity with virtually no effect on Rac1 or Cdc42 [34,35].
Neg (no) Regulation (effect) of Cdc42 associated with clostridium infection
2) Confidence 0.13 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.17 Pain Relevance 0
In each of these studies RhoA, Rac1 and Cdc42 were not significantly altered nor were they associated with aggressive or metastatic disease.
Neg (not) Regulation (altered) of Cdc42 associated with metastasis
3) Confidence 0.06 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.49 Pain Relevance 0.19

General Comments

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