INT183879

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.10
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOA) mitochondrion (RHOA) cell morphogenesis (RHOA)
intracellular (RHOA) GTPase activity (RHOA) cytoplasm (RHOA)
Anatomy Link Frequency
vesicles 1
RHOA (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 97.12 Very High Very High Very High
imagery 50 68.80 Quite High
cytokine 103 59.48 Quite High
Inflammation 97 58.52 Quite High
metalloproteinase 104 47.64 Quite Low
chemokine 25 5.00 Very Low Very Low Very Low
COX-2 inhibitor 23 5.00 Very Low Very Low Very Low
Kinase C 18 5.00 Very Low Very Low Very Low
agonist 14 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 44 99.20 Very High Very High Very High
Pancreatitis 2 97.12 Very High Very High Very High
Infection 191 93.40 High High
Cancer 195 92.80 High High
Adenocarcinoma 53 92.52 High High
Pancreatic Cancer 7 79.48 Quite High
Herpes Simplex Virus 238 75.92 Quite High
Adhesions 50 69.76 Quite High
INFLAMMATION 113 58.52 Quite High
Atherosclerosis 47 51.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whilst phosphorylation of RhoA at Ser188 does not apparently alter its association with either RhoGEFs or RhoGAPs (GTPase activating proteins), it significantly increases its interaction with RhoGDI (GDP dissociation inhibitor) thereby reducing the level of membrane bound RhoA and impairing its ability to activate its key effectors including Rho Kinases [36,46].
RhoA Binding (bound) of
1) Confidence 0.34 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
We have established Raichu-FLIM [37], whereby upon GTP binding, Rac1/Cdc42/RhoA exhibits a higher affinity towards the corresponding RhoGTPase-interacting domain, bringing the two different fluorescent proteins of the biosensor into close proximity and enabling FRET between GFP and mRFP1.
RhoA Binding (binding) of
2) Confidence 0.24 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.13 Pain Relevance 0.06
-Arrestin (ARRB1) is involved in the desensitization of receptors by targeting them to clathrin-coated vesicles through a RhoA and actin-dependent mechanism [60].
RhoA Binding (targeting) of in vesicles
3) Confidence 0.19 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.09 Pain Relevance 0
The bound active RhoA or Rac-1 is detected with a RhoA or Rac-1 specific antibody and quantitated by absorbance.
RhoA Binding (bound) of
4) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.21 Pain Relevance 0
In each of these studies RhoA, Rac1 and Cdc42 were not significantly altered nor were they associated with aggressive or metastatic disease.
RhoA Binding (associated) of associated with metastasis
5) Confidence 0.12 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.50 Pain Relevance 0.19
The Rho branch constitutes a second major branch, with RhoA, Rac1 and Cdc42 the most studied members.
RhoA Binding (branch) of
6) Confidence 0.08 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.17 Pain Relevance 0.06

General Comments

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