INT18388

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Context Info
Confidence 0.07
First Reported 1990
Last Reported 1998
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.34
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nasal 2
Nka1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 10 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
antagonist 6 99.74 Very High Very High Very High
qutenza 27 99.34 Very High Very High Very High
bradykinin 6 99.04 Very High Very High Very High
Nicotine 8 98.56 Very High Very High Very High
Calcium channel 3 97.52 Very High Very High Very High
Enkephalin 1 96.72 Very High Very High Very High
conotoxin 4 96.28 Very High Very High Very High
tetrodotoxin 3 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cough 2 97.32 Very High Very High Very High
Peritonitis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also inhibited CGRP and NKA release and bronchoconstriction caused by pH 5 buffer in lung, as well as cough and nasal irritation provoked by citric acid in vivo.
Negative_regulation (inhibited) of Localization (release) of NKA in nasal associated with cough and calcitonin gene-related peptide
1) Confidence 0.07 Published 1993 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 7694442 Disease Relevance 0.10 Pain Relevance 1.59
The capsaicin receptor antagonist capsazepine inhibited peptide (CGRP, NKA) release and bronchoconstriction produced by capsaicin but not that evoked by vagal stimulation, nicotine and bradykinin, suggesting selectivity.
Negative_regulation (inhibited) of Localization (release) of NKA associated with qutenza, nicotine, antagonist, bradykinin and calcitonin gene-related peptide
2) Confidence 0.06 Published 1993 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 7694442 Disease Relevance 0.10 Pain Relevance 1.54
The high K-evoked release of SP- and NKA-LI was dependent upon the presence of extracellular calcium and was inhibited by about 50% in the presence of the N-type voltage-dependent calcium channel blocker, omega-conotoxin GVIA (0.1 microM).
Negative_regulation (inhibited) of Localization (release) of NKA associated with calcium channel, conotoxin and substance p
3) Confidence 0.06 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9550295 Disease Relevance 0 Pain Relevance 0.61
The increased release of NKA was unaffected by hexamethonium.
Neg (unaffected) Negative_regulation (unaffected) of Localization (release) of NKA
4) Confidence 0.04 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 1972607 Disease Relevance 0.14 Pain Relevance 0.32

General Comments

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