INT183881

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.92
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDC42) plasma membrane (CDC42) cytoskeleton (CDC42)
intracellular (CDC42) GTPase activity (CDC42) cell division (CDC42)
Anatomy Link Frequency
muscle cell 1
CDC42 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 96.52 Very High Very High Very High
imagery 44 93.52 High High
tolerance 26 43.72 Quite Low
Kinase C 18 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
local anesthetic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 41 98.20 Very High Very High Very High
Pancreatitis 2 96.52 Very High Very High Very High
Cancer 157 92.20 High High
Adenocarcinoma 53 91.92 High High
Diabetes Mellitus 158 86.48 High High
Pancreatic Cancer 7 78.88 Quite High
Disease 39 66.84 Quite High
Insulin Resistance 70 59.44 Quite High
Impaired Glucose Tolerance 26 43.72 Quite Low
Renal Cancer 1 20.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CDC42 and PTBP1 were selected for study because they ranked highly as targets of miR-133/miR-206 in the TargetScan database and both proteins are relevant for muscle cell differentiation and metabolism [57,58].
Localization (selected) of CDC42 in muscle cell
1) Confidence 0.49 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0 Pain Relevance 0
As noted above, the wCCS correctly identified both CDC42 and PTBP1 protein abundance as unchanged and our protein analysis confirmed this.
Localization (abundance) of CDC42
2) Confidence 0.49 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.34 Pain Relevance 0
For monitoring localized small Rho GTPase activities (Cdc42, Rac1, RhoA) in cells, YFP-Raichu-CFP probes have been reported previously [70].
Localization (localized) of Cdc42
3) Confidence 0.16 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.09 Pain Relevance 0.05
In each of these studies RhoA, Rac1 and Cdc42 were not significantly altered nor were they associated with aggressive or metastatic disease.
Neg (not) Localization (altered) of Cdc42 associated with metastasis
4) Confidence 0.16 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.49 Pain Relevance 0.19

General Comments

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