INT18390

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPA) molecular_function (GYPA) cellular_component (GYPA)
biological_process (GYPA)
Anatomy Link Frequency
brain 2
nucleus 2
GYPA (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 96.48 Very High Very High Very High
Glutamate 3 91.32 High High
Serotonin 2 75.00 Quite High
antagonist 3 55.88 Quite High
Dopamine 78 5.00 Very Low Very Low Very Low
positron emission tomography 46 5.00 Very Low Very Low Very Low
imagery 23 5.00 Very Low Very Low Very Low
monoamine 6 5.00 Very Low Very Low Very Low
Substantia nigra 6 5.00 Very Low Very Low Very Low
midbrain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinsonian Disorders 39 95.04 Very High Very High Very High
Disease 66 93.80 High High
Congenital Anomalies 15 93.56 High High
Dystonia 2 90.48 High High
Tremor 12 84.64 Quite High
Paralysis 3 61.44 Quite High
Sialorrhea 1 39.20 Quite Low
Voice Disorders 1 38.64 Quite Low
Poisoning 2 28.40 Quite Low
Toxicity 1 5.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In decerebrate preparations, the firing index of spikes of MA.MNs monosynaptically evoked by stimulation of the trigeminal mesencephalic nucleus was increased by 5-HT and decreased by MS. 5-HT also enhanced the discharge of MA.MNs induced by a ramp-and-hold stretch of the masseter muscle.
Positive_regulation (enhanced) of Positive_regulation (induced) of MNs in nucleus
1) Confidence 0.40 Published 1990 Journal Brain Res. Section Abstract Doc Link 1972641 Disease Relevance 0.06 Pain Relevance 0.30
Besides occupational exposures, other conditions have been shown to increase accumulation of Mn in the brain and have been valuable sources of information in understanding Mn-induced neurological dysfunction, including parkinsonism.
Positive_regulation (increase) of Positive_regulation (accumulation) of Mn in brain associated with anesthesia and parkinsonian disorders
2) Confidence 0.14 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 1.35 Pain Relevance 0.10

General Comments

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