INT18391

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 41
Total Number 42
Disease Relevance 16.47
Pain Relevance 8.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPA) molecular_function (GYPA) cellular_component (GYPA)
biological_process (GYPA)
Anatomy Link Frequency
brain 7
MnPO 6
VMH 4
striatum 2
MNs 2
GYPA (Homo sapiens)
Pain Link Frequency Relevance Heat
repetitive firing 3 99.92 Very High Very High Very High
Pain 30 99.80 Very High Very High Very High
anesthesia 23 99.76 Very High Very High Very High
Angina 10 99.28 Very High Very High Very High
imagery 349 98.38 Very High Very High Very High
Dopamine 1170 98.28 Very High Very High Very High
lidocaine 6 98.08 Very High Very High Very High
Nicotine 6 97.92 Very High Very High Very High
Transcranial magnetic stimulation 3 97.92 Very High Very High Very High
Intracerebroventricular 6 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 23 100.00 Very High Very High Very High
Hypertension 13 100.00 Very High Very High Very High
Pain 22 99.80 Very High Very High Very High
Parkinson's Disease 57 99.72 Very High Very High Very High
Cv General 3 Under Development 8 99.28 Very High Very High Very High
Myocardial Infarction 39 98.32 Very High Very High Very High
Parkinsonian Disorders 585 98.20 Very High Very High Very High
Infection 48 98.12 Very High Very High Very High
Disease 1008 97.92 Very High Very High Very High
Alcoholic Liver Cirrhosis 15 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Healthy participants viewed short videos known to activate the sensorimotor MNS for pain (a needle penetrating a human hand) while transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEP) were recorded as a measure of motor cortex excitability.
Positive_regulation (activate) of MNS in cortex associated with pain and transcranial magnetic stimulation
1) Confidence 0.40 Published 2008 Journal Psychiatry Res Section Abstract Doc Link 18599127 Disease Relevance 0.45 Pain Relevance 0.30
In decerebrate preparations, the firing index of spikes of MA.MNs monosynaptically evoked by stimulation of the trigeminal mesencephalic nucleus was increased by 5-HT and decreased by MS. 5-HT also enhanced the discharge of MA.MNs induced by a ramp-and-hold stretch of the masseter muscle.
Positive_regulation (induced) of MNs in nucleus
2) Confidence 0.40 Published 1990 Journal Brain Res. Section Abstract Doc Link 1972641 Disease Relevance 0.06 Pain Relevance 0.29
The patients were randomly assigned to receive IS-5-MN or placebo, and after 1 week of therapy were crossed over to the other formulations.
Positive_regulation (receive) of IS-5-MN
3) Confidence 0.37 Published 1990 Journal Am. J. Cardiol. Section Abstract Doc Link 2190464 Disease Relevance 0.33 Pain Relevance 0.29
This is in agreement with our previous findings where we demonstrated an age-associated increase in Mn-SOD activity in recreationally active older adults compared to young subjects [33].
Positive_regulation (increase) of Mn-SOD
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.13 Pain Relevance 0
Twenty-one median preoptic nucleus (MnPO) neurons in normotensive Wistar-Kyoto rats (WKY) and 18 MnPO neurons in spontaneously hypertensive rats (SHR) were antidromically activated by electrical stimulation of the hypothalamic paraventricular nucleus (PVN) under urethane anesthesia.
Positive_regulation (activated) of MnPO in MnPO associated with anesthesia and hypertension
5) Confidence 0.25 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7659288 Disease Relevance 0.17 Pain Relevance 0.10
Twenty-one median preoptic nucleus (MnPO) neurons in normotensive Wistar-Kyoto rats (WKY) and 18 MnPO neurons in spontaneously hypertensive rats (SHR) were antidromically activated by electrical stimulation of the hypothalamic paraventricular nucleus (PVN) under urethane anesthesia.
Positive_regulation (activated) of MnPO in MnPO associated with anesthesia and hypertension
6) Confidence 0.25 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7659288 Disease Relevance 0.17 Pain Relevance 0.10
Activation of MNS areas has been shown to increase during social interaction, as well as during observation and imitation of emotional faces [25].
Positive_regulation (Activation) of MNS in faces
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877098 Disease Relevance 0.46 Pain Relevance 0.19
On the other hand, the selective response of vegans to animals in the ACC (with reduced amygdala responses) might reflect a greater attribution of self-relevance [13] and a greater recruitment of emotional regulation mechanisms [15], [26] when viewing negative states of non-human beings, together with an enhanced activation of the motor MNS and inhibitory control processes mediated through the MFG and the IFG, respectively.
Positive_regulation (activation) of MNS in amygdala associated with amygdala and anterior cingulate cortex
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877098 Disease Relevance 0.15 Pain Relevance 0.36
Electrical stimulation of the MnPO and the paraventricular nucleus of the hypothalamus (PVN) elicited an increase in RSNA.
Positive_regulation (stimulation) of MnPO in hypothalamus
9) Confidence 0.22 Published 2000 Journal Brain Res. Section Abstract Doc Link 10837803 Disease Relevance 0 Pain Relevance 0.23
Exercise time to the onset of angina 2 and 6 hours after administration increased after 20 mg IS-5MN (5.88 +/- 1.85; P less than 0.001 and 5.08 +/- 1.97 minutes; P less than 0.002) and 40 mg IS-5MN (6.17 +/- 1.88; P less than 0.001 and 5.78 +/- 1.72 minutes; P less than 0.001) in comparison to placebo (4.57 +/- 1.22 and 4.15 +/- 1.22 minutes).
Positive_regulation (increased) of IS-5MN associated with angina
10) Confidence 0.21 Published 1987 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 3595067 Disease Relevance 0.33 Pain Relevance 0.30
Together, these results suggest that physical activity preserves Mn-SOD activity in AO individuals, likely due to attenuation of age-associated nitration of Mn-SOD.
Positive_regulation (preserves) of Mn-SOD
11) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.33 Pain Relevance 0.06
The mitochondrial antioxidant enzyme milieu of active older adults provides an intra-organellar environment conducive to O-.2 dismutation via maintenance of their Mn-SOD activity at levels similar to those found in young subjects, despite an aging-associated decline in Mn-SOD content in skeletal muscle.
Positive_regulation (maintenance) of Mn-SOD in skeletal muscle associated with aging
12) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.67 Pain Relevance 0.08
We compared the effects of stimulation of MNs by electrical field stimulation (26 V, 0.3-20 Hz); nicotine (1-300 micromol L(-1)); 5-HT and 2-Me-5-HT (1 nmol(-1)-30 micromol L(-1)); and alpha,beta-methylene ATP (alpha,beta-meATP 1-100 micromol L(-1)); in standard Krebs solution; a non-adrenergic non-nitrergic non-purinergic (NANNNP) solution; and a non-adrenergic non-cholinergic (NANC) solution.
Positive_regulation (stimulation) of MNs in MNs associated with nicotine
13) Confidence 0.19 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19614864 Disease Relevance 0 Pain Relevance 0.08
Inhibitory MNs are strongly stimulated by nAChRs and do not respond to stimulation of 5-HT(3) and P2X receptors.
Positive_regulation (stimulated) of MNs in MNs
14) Confidence 0.19 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19614864 Disease Relevance 0 Pain Relevance 0.60
This single subject had parkinsonian symptoms and elevated Mn in the blood and was responsive to l-dopa therapy, a clinical response that has not been observed in Mn-induced parkinsonism.
Positive_regulation (elevated) of Mn in blood associated with parkinson's disease and parkinsonian disorders
15) Confidence 0.19 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.88 Pain Relevance 0.13
Thus, it is a sensitive method for detecting small increases in brain Mn concentrations.
Positive_regulation (increases) of Mn in brain
16) Confidence 0.19 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0 Pain Relevance 0.51
These findings have been confirmed by other investigators, and subsequent studies have shown that although the basal ganglia is one of the first to accumulate Mn, other brain structures also accumulate the metal, albeit to a lesser extent (Dorman et al. 2006; Ingersoll et al. 2006b).
Positive_regulation (accumulate) of Mn in basal ganglia
17) Confidence 0.19 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0 Pain Relevance 0.49
Table 1 outlines the motor symptoms from the literature related to occupational Mn exposures and other human conditions in which Mn levels are markedly increased in the brain, and the motor symptoms in idiopathic PD.
Positive_regulation (increased) of Mn in brain associated with disease
18) Confidence 0.19 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 1.56 Pain Relevance 0
As pointed out by Perl and Olanow (2007), a very limited number of autopsy studies have been performed on workers who were exposed to Mn or on persons with other related conditions in which Mn was increased in the brain (Table 3).
Positive_regulation (increased) of Mn in brain
19) Confidence 0.19 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.65 Pain Relevance 0.09
Thus, it is possible that a progressive accumulation of Mn occurred in the striatum that reached concentrations sufficient to interfere with radioligand binding to DAT.
Positive_regulation (accumulation) of Mn in striatum
20) Confidence 0.19 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.18 Pain Relevance 0.26

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