INT183910

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 9.78
Pain Relevance 6.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Lbp) transport (Lbp) extracellular space (Lbp)
extracellular region (Lbp)
Anatomy Link Frequency
macrophages 3
muscle 2
monocytes 1
Lbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 493 100.00 Very High Very High Very High
imagery 63 99.20 Very High Very High Very High
Pain 157 95.60 Very High Very High Very High
chemokine 4 94.40 High High
Inflammation 66 82.88 Quite High
Dysuria 1 57.80 Quite High
Sciatica 5 33.52 Quite Low
rheumatoid arthritis 80 14.68 Low Low
cytokine 18 10.88 Low Low
metalloproteinase 16 9.76 Low Low
Disease Link Frequency Relevance Heat
Low Back Pain 503 100.00 Very High Very High Very High
Osteomyelitis 2 99.48 Very High Very High Very High
Pyelonephritis 2 98.36 Very High Very High Very High
Infection 89 97.84 Very High Very High Very High
Soft Tissue Infections 2 97.20 Very High Very High Very High
Pain 173 95.60 Very High Very High Very High
Pneumonia 3 95.48 Very High Very High Very High
Obesity 4 93.72 High High
Repression 2 92.16 High High
Fasciitis 2 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies indicate the need to take into account multiple work and life factors that can be changed to help reduce the prevalence of LBP, including daily life conditions (lifestyle and dietary habits), job-related factors (work activities and workplace environment), and psychological factors.
Negative_regulation (reduce) of Gene_expression (prevalence) of LBP associated with backache
1) Confidence 0.35 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1971070 Disease Relevance 0.78 Pain Relevance 0.69
Is there an association between the diagnostic classification and the course pattern of LBP or total number of LBP days?
Negative_regulation (number) of Gene_expression (days) of LBP associated with backache
2) Confidence 0.30 Published 2010 Journal Chiropr Osteopat Section Body Doc Link PMC2868855 Disease Relevance 2.10 Pain Relevance 2.10
An attractive hypothesis for WAY-169916-mediated activity in the spleen involves the downregulation of LBP and CD14 expression on monocytes and macrophages, resulting in a diminished immune response and ultimately resulting in the observed decreases in MMP9, IL1R2, chemokine-like factor 1, S100A8, and S100A9 through the repression of NF-?
Negative_regulation (downregulation) of in monocytes Gene_expression (expression) of LBP in macrophages associated with chemokine and repression
3) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 0.31 Pain Relevance 0.16
Subsequently, the LBP subjects received OMT and then another MRI.
Negative_regulation (received) of Gene_expression (subjects) of LBP associated with imagery and backache
4) Confidence 0.23 Published 2009 Journal Osteopath Med Prim Care Section Body Doc Link PMC2744922 Disease Relevance 0.82 Pain Relevance 0.94
Although the data are not included, muscle cross sectional areas were measured in this study, and no differences were detected either between LBP subjects and controls or within LBP subject before and after treatment.
Negative_regulation (detected) of Gene_expression (subjects) of LBP in muscle associated with backache
5) Confidence 0.23 Published 2009 Journal Osteopath Med Prim Care Section Body Doc Link PMC2744922 Disease Relevance 0.95 Pain Relevance 0.42
The detection limit of LBP was 0.2 ?
Negative_regulation (limit) of Gene_expression (detection) of LBP
6) Confidence 0.11 Published 2006 Journal Crit Care Section Body Doc Link PMC1550885 Disease Relevance 0.98 Pain Relevance 0.09
An attractive hypothesis for WAY-169916-mediated activity in the spleen involves the downregulation of LBP and CD14 expression on monocytes and macrophages, resulting in a diminished immune response and ultimately resulting in the observed decreases in MMP9, IL1R2, chemokine-like factor 1, S100A8, and S100A9 through the repression of NF-?
Negative_regulation (downregulation) of Gene_expression (expression) of LBP in macrophages associated with chemokine and repression
7) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 0.31 Pain Relevance 0.16
Differences in levels of HMGB1, LBP, IL6 and CRP between groups of different severity of infection
Negative_regulation (Differences) of Gene_expression (levels) of LBP associated with infection
8) Confidence 0.09 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 1.78 Pain Relevance 0
Part 4 dealt with GPs' formation of practice and practice for LBP: participation in an educational session on LBP in the last 3 years (yes/no); mean length of sick leave prescription for acute LBP if needed (?
Negative_regulation (dealt) of Gene_expression (practice) of LBP associated with backache
9) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1939729 Disease Relevance 0.87 Pain Relevance 0.80
Part 4 dealt with GPs' formation of practice and practice for LBP: participation in an educational session on LBP in the last 3 years (yes/no); mean length of sick leave prescription for acute LBP if needed (?
Negative_regulation (session) of Gene_expression (participation) of LBP associated with backache
10) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1939729 Disease Relevance 0.87 Pain Relevance 0.80

General Comments

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