INT183933

Context Info Confidence 0.31 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 8.74 Pain Relevance 1.06

endosome (CD68) plasma membrane (CD68)

Anatomy Link Frequency macrophage 4 smooth muscle 2 monocytes 1 CD68 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 54 99.30 rheumatoid arthritis 86 98.56 cytokine 13 97.40 metalloproteinase 7 91.04 Arthritis 142 88.96 abdominal pain 3 78.00 Pain 7 33.32 methotrexate 9 32.00 imagery 3 9.64 agonist 35 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 51 99.30 Apoptosis 2 99.10 Rheumatoid Arthritis 87 98.56 Pulmonary Disease 131 98.32 Hyperplasia 7 97.82 Cancer 92 96.68 Necrosis 19 96.40 Confusion 2 92.84 Transitional Cell Carcinoma 7 92.80 Malignant Neoplastic Disease 14 90.72

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Anatomy

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Speculation

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Immunohistochemical analysis performed on paraffin-embedded tissue sections was negative for pan-cytokeratin 7 and 20, epithelial membrane antigen (EMA), as well as a smooth muscle actin, desmin, CD34 and CD68.

CD68 Binding (actin) of in smooth muscle

1) Confidence 0.31 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2843711 Disease Relevance 0.92 Pain Relevance 0

Lining layer hyperplasia appeared to be more pronounced in RA, both by altered apoptosis of lining cells as by increased presence of CD68+ macrophage-like synoviocytes, although macrophage-derived pro-inflammatory cytokines such as tumour necrosis factor-?

CD68 Binding (macrophage) of in macrophage associated with necrosis, inflammation, cancer, rheumatoid arthritis, apoptosis, hyperplasia and cytokine

2) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 1.88 Pain Relevance 0.78

The neoplastic cells demonstrated immunohistochemical staining characteristics similar to those of normal monocytes/histiocytes, namely strong immunoreactivity with CD163, CD68, lysozyme, NSE, and vimentin.

CD68 Binding (immunoreactivity) of in histiocytes

3) Confidence 0.27 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.59 Pain Relevance 0

Immunostaining with CD68 was positive, and CD1a stained only a few intraepidermal and rare dermal cells.

CD68 Binding (Immunostaining) of

4) Confidence 0.26 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 0.28 Pain Relevance 0

The spindle cells were found to be positive for vimentin and smooth muscle actin and negative for desmin, S-100 protein, myogenin and CD68 on immunohistochemistry.

CD68 Binding (negative) of in smooth muscle

5) Confidence 0.25 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2873452 Disease Relevance 0.69 Pain Relevance 0

The neoplastic cells demonstrated immunohistochemical staining characteristics similar to those of normal monocytes/histiocytes, namely strong immunoreactivity with CD163, CD68, lysozyme, NSE, and vimentin.

CD68 Binding (immunoreactivity) of in monocytes

6) Confidence 0.09 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.59 Pain Relevance 0

Macrophages were the predominant inflammatory cells within lesions, as shown by immunoreactivity for the macrophage markers Iba1 and CD68.

CD68 Binding (immunoreactivity) of in macrophage associated with inflammation

7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3009713 Disease Relevance 0.71 Pain Relevance 0.10

Cilomilast at a dose of 15 mg twice daily for 12 weeks reduces CD4+ T-lymphocyte subsets and CD68+ macrophages in bronchial biopsies from patients with COPD (Gamble et al 2003).

CD68 Binding (macrophages) of in macrophages associated with pulmonary disease

8) Confidence 0.06 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707800 Disease Relevance 1.08 Pain Relevance 0.18

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