INT183937

Context Info Confidence 0.50 First Reported 2005 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 3.39 Pain Relevance 1.81

transport (Ank) plasma membrane (Ank)

Anatomy Link Frequency articular cartilage 1 Ank (Mus musculus)

Pain Link Frequency Relevance Heat spinal inflammation 229 99.50 Osteoarthritis 15 97.76 Lasting pain 2 53.28 Inflammation 4 45.84 spondylitis 10 5.00 Arthritis 6 5.00 cytokine 3 5.00 depression 2 5.00 adenocard 2 5.00 Pain score 2 5.00

Disease Link Frequency Relevance Heat Seronegative Spondarthritis 230 99.50 Ankylosis 10 99.12 Calcification 46 98.76 Chondrocalcinosis 3 98.20 Osteoarthritis 15 97.76 Aging 13 84.48 Disease 28 76.08 Recurrence 6 57.24 Pain 4 53.28 Osteoporosis 4 51.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PPi export from the cell is regulated by the ANK protein [7], and mutant mice (ank/ank), which have a premature stop codon in the 3' end of the ank gene, develop severe ankylosis.

Positive_regulation (end) of ank associated with ankylosis

1) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174945 Disease Relevance 0.86 Pain Relevance 0.59

Haplotype analyses appeared to confirm the results of the single-marker tests (FBAT analyses), indicating that the predisposing polymorphism(s) for men with AS probably lies at the 3' end of the ANKH gene, whereas those for affected women are probably at the 5' end of the gene.

Positive_regulation (end) of ANKH associated with spinal inflammation

2) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174945 Disease Relevance 0.94 Pain Relevance 0.94

This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.

Positive_regulation (defective) of ANK in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis

3) Confidence 0.46 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.59 Pain Relevance 0.28

General Comments

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