INT183937

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.39
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ank) plasma membrane (Ank)
Anatomy Link Frequency
articular cartilage 1
Ank (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 229 99.50 Very High Very High Very High
Osteoarthritis 15 97.76 Very High Very High Very High
Lasting pain 2 53.28 Quite High
Inflammation 4 45.84 Quite Low
spondylitis 10 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Pain score 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 230 99.50 Very High Very High Very High
Ankylosis 10 99.12 Very High Very High Very High
Calcification 46 98.76 Very High Very High Very High
Chondrocalcinosis 3 98.20 Very High Very High Very High
Osteoarthritis 15 97.76 Very High Very High Very High
Aging 13 84.48 Quite High
Disease 28 76.08 Quite High
Recurrence 6 57.24 Quite High
Pain 4 53.28 Quite High
Osteoporosis 4 51.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PPi export from the cell is regulated by the ANK protein [7], and mutant mice (ank/ank), which have a premature stop codon in the 3' end of the ank gene, develop severe ankylosis.
Positive_regulation (end) of ank associated with ankylosis
1) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174945 Disease Relevance 0.86 Pain Relevance 0.59
Haplotype analyses appeared to confirm the results of the single-marker tests (FBAT analyses), indicating that the predisposing polymorphism(s) for men with AS probably lies at the 3' end of the ANKH gene, whereas those for affected women are probably at the 5' end of the gene.
Positive_regulation (end) of ANKH associated with spinal inflammation
2) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174945 Disease Relevance 0.94 Pain Relevance 0.94
This model presents mechanisms underlying the common association of extracellular PPi excess with both CPPD and HA crystal deposition in OA and chondrocalcinosis cartilages, as well as the paradoxical association of extracellular PPi deficiency (from defective ANK or PC-1/NPP1 expression) with pathologic calcification of articular cartilage with HA crystals in vivo.
Positive_regulation (defective) of ANK in articular cartilage associated with chondrocalcinosis, calcification and osteoarthritis
3) Confidence 0.46 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 1.59 Pain Relevance 0.28

General Comments

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