INT18394

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 0.28
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ryr1) plasma membrane (Ryr1) cytoplasm (Ryr1)
Ryr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 30 100.00 Very High Very High Very High
Clonidine 15 99.72 Very High Very High Very High
opiate 3 98.84 Very High Very High Very High
antagonist 12 98.56 Very High Very High Very High
narcan 3 98.12 Very High Very High Very High
anesthesia 7 93.76 High High
agonist 5 91.56 High High
Neurotransmitter 5 91.52 High High
Potency 3 89.04 High High
Adelta 1 89.04 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 29 91.12 High High
Repression 2 53.92 Quite High
Targeted Disruption 4 34.08 Quite Low
Increased Venous Pressure Under Development 4 15.76 Low Low
Shock 15 5.00 Very Low Very Low Very Low
Ataxia 6 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From these studies, we found that six triadic proteins, that are known to regulate RyR1 function and/or EC coupling [TRPC1, JP2 (junctophilin 2), homer, mitsugumin 29, calreticulin and calmodulin], interacted directly with TRPC3 in a Ca2+-independent manner.
Regulation (regulate) of RyR1
1) Confidence 0.60 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.07
Our results indicate that only the RyR channel drugs modulated the anesthetic effects of bupivacaine.
Regulation (modulated) of RyR
2) Confidence 0.36 Published 2004 Journal Eur J Pain Section Abstract Doc Link 14987625 Disease Relevance 0 Pain Relevance 1.02
The altered Ca2+ homeostasis in PC caused by P/Q-calcium channel mutations could be compensated by various ways; increased activities of N and L type calcium channels (Jun et al., 1999), modulation of calcium binding proteins, and down regulation of intracellular calcium channels such as ryanodine receptor 1(RyR1) (Cicale et al., 2002).
Regulation (regulation) of RyR1 associated with calcium channel
3) Confidence 0.23 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015039 Disease Relevance 0.05 Pain Relevance 0.15
The altered Ca2+ homeostasis in PC caused by P/Q-calcium channel mutations could be compensated by various ways; increased activities of N and L type calcium channels (Jun et al., 1999), modulation of calcium binding proteins, and down regulation of intracellular calcium channels such as ryanodine receptor 1(RyR1) (Cicale et al., 2002).
Regulation (regulation) of ryanodine receptor 1 associated with calcium channel
4) Confidence 0.23 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015039 Disease Relevance 0.05 Pain Relevance 0.15
Because RyRs are involved in hippocampal L-LTP [44], dysfunction of RyR regulation in KO mice may lead to an impairment in L-LTP formation.
Regulation (regulation) of RyR
5) Confidence 0.19 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.17 Pain Relevance 0.07
The Ca(++)-evoked release of [3H]norepinephrine was used in these studies to investigate presynaptic regulation of norepinephrine release.
Spec (investigate) Regulation (regulation) of release
6) Confidence 0.00 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1972747 Disease Relevance 0 Pain Relevance 0.26
Release was unaffected by 5 microM idazoxan or the opiate antagonist naloxone at 15 or 20 mM [K+].
Neg (unaffected) Regulation (unaffected) of Release associated with antagonist, narcan and opiate
7) Confidence 0.00 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1972747 Disease Relevance 0 Pain Relevance 0.80
Neither clonidine nor idazoxan affected Ca(++)-evoked release with the K+ channel blockers present.
Neg (Neither) Regulation (affected) of release associated with clonidine
8) Confidence 0.00 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1972747 Disease Relevance 0 Pain Relevance 0.75

General Comments

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