INT18396

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 2.45
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ryr1) plasma membrane (Ryr1) cytoplasm (Ryr1)
Anatomy Link Frequency
macrophages 1
caudate nucleus 1
muscle 1
myotubes 1
reticulum 1
Ryr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 7 100.00 Very High Very High Very High
agonist 25 99.36 Very High Very High Very High
addiction 39 99.02 Very High Very High Very High
Inflammation 70 98.00 Very High Very High Very High
Pain 32 97.66 Very High Very High Very High
antagonist 19 97.60 Very High Very High Very High
cytokine 44 95.92 Very High Very High Very High
Clonidine 11 95.48 Very High Very High Very High
dopamine receptor 1 92.48 High High
isoflurane 2 91.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 96 98.00 Very High Very High Very High
Pain 32 97.66 Very High Very High Very High
Contracture 8 96.84 Very High Very High Very High
Malignant Hyperthermia 68 93.44 High High
Heat Stress Disorders 1 92.16 High High
Disease 33 89.40 High High
Neuropathic Pain 28 78.20 Quite High
Targeted Disruption 22 75.00 Quite High
Hypokalemic Periodic Paralysis 29 68.24 Quite High
Muscle Rigidity 1 62.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The R163C mutation has been shown to cause RYR1 to be activated more easily by agonists (Yang et al., 2006), which may indicate that it enters more easily into the ECC-activated conformation.
Positive_regulation (activated) of RYR1 associated with agonist
1) Confidence 0.58 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0.05
In addition, the heterozygous expression of the mutation results in enhanced RyR1 sensitivity to activation by temperature, caffeine, and voltage but not uncompensated sarcoplasmic reticulum calcium leak or store depletion.
Neg (not) Positive_regulation (enhanced) of RyR1 in reticulum
2) Confidence 0.50 Published 2006 Journal FASEB J. Section Abstract Doc Link 16284304 Disease Relevance 0.76 Pain Relevance 0.19
Moreover, a conformational change of RYR1 that is induced by exposure to high ryanodine causes a 2-nm decrease in distance between adjacent tetradic particles, further supporting the hypothesis that DHPRs are docked to RYR1 (Paolini et al., 2004).
Positive_regulation (induced) of RYR1
3) Confidence 0.42 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.05 Pain Relevance 0
The model is based on the simple idea that the free energy for activation of RYR1 upon depolarization, and its deactivation upon repolarization, is provided by the movement of DHPR charged residues (designated “Q” in Fig. 6) through the membrane field.
Positive_regulation (activation) of RYR1
4) Confidence 0.42 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0.03
1 subunits (also termed dihydropyridine receptors, DHPRs, in muscle) mechanically activate RyR1 and elicit SR Ca2+ release.
Positive_regulation (activate) of RyR1 in muscle
5) Confidence 0.31 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.14 Pain Relevance 0
1S was entirely typical of skeletal myotubes with sigmoidal voltage-dependence, proceeding in the absence of external Ca2+ and requiring RyR1.
Positive_regulation (requiring) of RyR1 in myotubes associated with addiction
6) Confidence 0.27 Published 2001 Journal BMC Physiol Section Body Doc Link PMC64647 Disease Relevance 0 Pain Relevance 0.05
ATP-stimulation of P2X7 results in the rapid activation of caspase-1 in macrophages and the release of mature, biologically active, IL-1?
Positive_regulation (activation) of release in macrophages
7) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.18 Pain Relevance 0.12
The role of P2X7 in pain and inflammation

The P2X7 purinoceptor is unique amongst the P2X receptor family in that its activation is able to stimulate the release of mature, biologically active interleukin-1?

Positive_regulation (stimulate) of release associated with pain and inflammation
8) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Title Doc Link PMC2096758 Disease Relevance 0.76 Pain Relevance 0.60
Increasing the [K+] before Ca++ exposure increased [3H]norepinephrine release, and at 20 [K+] the release increased to over 20% of total stores.
Positive_regulation (increased) of release
9) Confidence 0.00 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1972747 Disease Relevance 0 Pain Relevance 0.75
Increasing the [K+] before Ca++ exposure increased [3H]norepinephrine release, and at 20 [K+] the release increased to over 20% of total stores.
Positive_regulation (increased) of release
10) Confidence 0.00 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1972747 Disease Relevance 0 Pain Relevance 0.72
It was found that the L to V but not the P to S mutation of the RyR1 resulted in enhanced Ca2+ release activity.
Positive_regulation (enhanced) of release
11) Confidence 0.00 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11928716 Disease Relevance 0.55 Pain Relevance 0.07
In caudate nucleus slices urapidil (greater than 1 microM) significantly facilitated both the evoked ACh- and DA-release, effects which were enhanced by the DA-reuptake inhibitor nomifensine.
Positive_regulation (facilitated) of DA-release in caudate nucleus associated with dopamine
12) Confidence 0.00 Published 1987 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2883943 Disease Relevance 0 Pain Relevance 0.81

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