INT183967

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 9.04
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Btg3)
Anatomy Link Frequency
joints 1
blood 1
Btg3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 84 99.96 Very High Very High Very High
Inflammation 81 98.60 Very High Very High Very High
Multiple sclerosis 5 92.08 High High
imagery 2 87.04 High High
Neuritis 8 82.12 Quite High
Infliximab 34 80.92 Quite High
methotrexate 8 67.36 Quite High
Fibrositis 35 67.08 Quite High
Etanercept 36 59.92 Quite High
cytokine 11 58.44 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 84 99.96 Very High Very High Very High
Rheumatic Diseases 101 99.92 Very High Very High Very High
Disease 200 98.92 Very High Very High Very High
Dermatomyositis 25 98.80 Very High Very High Very High
Systemic Lupus Erythematosus 323 98.68 Very High Very High Very High
INFLAMMATION 82 98.60 Very High Very High Very High
Autoimmune Disease 51 96.96 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 5 95.24 Very High Very High Very High
Neurologic Manifestations 2 95.24 Very High Very High Very High
Exanthema 20 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 47 ALL children, 8 (17%) had an elevated ANA titer [21].
Positive_regulation (elevated) of ANA
1) Confidence 0.58 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 1.10 Pain Relevance 0.03
Since the introduction of the indirect immunofluorescence (IF) test for antinuclear antibodies (ANA) by Friou in 1957 [1], ordering an ANA appears to have become a reflexive response to the question "could this patient have a rheumatic disease?"
Positive_regulation (test) of ANA associated with rheumatic diseases
2) Confidence 0.42 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 0.37 Pain Relevance 0
Development of rheumatic diseases in ANA positive individuals
Positive_regulation (individuals) of ANA associated with rheumatic diseases
3) Confidence 0.42 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 1.32 Pain Relevance 0.17
Tellingly, it wasn't the elevated ANA titer that distinguished the children with JRA from those with other musculoskeletal problems, but the history (e.g., morning stiffness) and the physical exam (e.g., presence of rash, swollen joints).
Positive_regulation (elevated) of ANA in joints associated with exanthema and rheumatoid arthritis
4) Confidence 0.42 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 1.42 Pain Relevance 0.24
This combination was also found in 12.5% of ANA positive JRA and 5.4% of ANA positive JDM patients.
Positive_regulation (positive) of ANA associated with rheumatoid arthritis and dermatomyositis
5) Confidence 0.39 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2987328 Disease Relevance 0.85 Pain Relevance 0.05
Increased levels of ANA were observed at 13 wks, and age-dependent increase in anti-SSB/La autoantibody was also presented; however, no significant difference in anti-SSA/Ro autoantibody was seen when compared with wild-type controls.
Positive_regulation (Increased) of ANA
6) Confidence 0.17 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 0.67 Pain Relevance 0.06
Our previous study showed a remarkable increase in the levels of autoantibodies including anti-double strand DNA (dsDNA) IgG and IgM antibodies, and anti-nuclear antibody (ANA) in the peripheral blood [17].
Positive_regulation (increase) of ANA in blood
7) Confidence 0.09 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 1.10 Pain Relevance 0
Biological signs were positive results for ANA in all patients (new onset or rise in titre, range 1/160–1/2560°; four with a speckled pattern, eight with a diffuse pattern), and positive results for anti-dsDNA antibodies (new onset) in 11 patients by ELISA.
Positive_regulation (results) of ANA
8) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174953 Disease Relevance 1.11 Pain Relevance 0.36
Biological signs were positive results for ANA in all patients (new onset or rise in titre, range 1/160–1/250°; three patients with a speckled pattern, seven patients with a diffuse pattern).
Positive_regulation (results) of ANA
9) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174953 Disease Relevance 1.10 Pain Relevance 0.12

General Comments

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