INT18399

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Context Info
Confidence 0.53
First Reported 1990
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.78
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Glp1r) signal transducer activity (Glp1r)
Anatomy Link Frequency
stomach 2
Plasma 1
ileum 1
colon 1
Glp1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 6 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
Somatostatin 22 99.24 Very High Very High Very High
Chronic pancreatitis 17 98.96 Very High Very High Very High
Neurotransmitter 5 98.48 Very High Very High Very High
agonist 25 98.04 Very High Very High Very High
antagonist 4 97.60 Very High Very High Very High
qutenza 5 94.48 High High
tetrodotoxin 5 67.20 Quite High
Cholecystokinin 2 61.36 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 3 100.00 Very High Very High Very High
Pancreatitis 18 98.96 Very High Very High Very High
Steatorrhea 3 97.96 Very High Very High Very High
Hypertension 9 96.12 Very High Very High Very High
Myocardial Infarction 208 95.68 Very High Very High Very High
Diabetes Mellitus 102 95.28 Very High Very High Very High
Appetite Loss 5 94.00 High High
Hyperlipidemia 10 92.84 High High
Body Weight 39 91.08 High High
Insulin Resistance 37 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies did not identify the molecular mechanisms mediating the GLP-1 and AC3174 changes in physiological function.
Regulation (changes) of GLP-1
1) Confidence 0.53 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.48 Pain Relevance 0
The effect of glucagon-like peptide-1 (GLP-1) amide on gastric somatostatin and gastrin secretion was investigated in the isolated, vascularly perfused rat stomach preparation.
Regulation (effect) of GLP-1 in stomach associated with somatostatin
2) Confidence 0.44 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 1972810 Disease Relevance 0 Pain Relevance 0.27
The effect of glucagon-like peptide-1 (GLP-1) amide on gastric somatostatin and gastrin secretion was investigated in the isolated, vascularly perfused rat stomach preparation.
Regulation (effect) of glucagon-like peptide-1 in stomach associated with somatostatin
3) Confidence 0.44 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 1972810 Disease Relevance 0 Pain Relevance 0.26
Compared with the vehicle control group, PVO2 was not significantly changed in sham-operated and GLP-1 or AC3174 treated groups.
Neg (not) Regulation (changed) of GLP-1
4) Confidence 0.39 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.40 Pain Relevance 0
Regulation of glucagon-like peptide-1-(7-36) amide secretion by intestinal neurotransmitters and hormones in the isolated vascularly perfused rat colon.
Regulation (Regulation) of glucagon-like peptide-1 in colon associated with neurotransmitter and neuropeptide
5) Confidence 0.24 Published 1994 Journal Endocrinology Section Title Doc Link 7988423 Disease Relevance 0 Pain Relevance 0.26
Regulation of glucagon-like peptide-1-(7-36) amide, peptide YY, and neurotensin secretion by neurotransmitters and gut hormones in the isolated vascularly perfused rat ileum.
Regulation (Regulation) of glucagon-like peptide-1 in ileum associated with neurotransmitter
6) Confidence 0.23 Published 1995 Journal Endocrinology Section Title Doc Link 7588257 Disease Relevance 0 Pain Relevance 0.11
Plasma levels of ghrelin, peptide YY, glucagon-like peptide 1, and apolipoprotein A-IV were not changed by OEA.
Neg (not) Regulation (changed) of glucagon-like peptide 1 in Plasma associated with disorder of lipid metabolism
7) Confidence 0.20 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15879057 Disease Relevance 0.57 Pain Relevance 0.19
Future studies from us will estimate the effects of this DPP-IV inhibitor on the enzyme activity/expression, as well as on levels of GLP-1 and glucagon, in order to have a more detailed picture of how the incretins pathway is affected and its relative contribution for the effects of sitagliptin here reported.
Regulation (effects) of GLP-1
8) Confidence 0.14 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2905949 Disease Relevance 1.06 Pain Relevance 0
Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution.
Regulation (responses) of GLP-1 associated with steatorrhea and chronic pancreatitis
9) Confidence 0.11 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 16954337 Disease Relevance 0.45 Pain Relevance 0.35
We aimed to investigate how assimilation of nutrients affects the postprandial responses of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) and to evaluate the effect of pancreatic enzyme substitution (PES) on insulin secretion in patients with chronic pancreatitis (CP) and pancreatic exocrine insufficiency (PEI).
Regulation (affects) of glucagon-like peptide-1 associated with chronic pancreatitis
10) Confidence 0.11 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16954337 Disease Relevance 0.41 Pain Relevance 0.34
We aimed to investigate how assimilation of nutrients affects the postprandial responses of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) and to evaluate the effect of pancreatic enzyme substitution (PES) on insulin secretion in patients with chronic pancreatitis (CP) and pancreatic exocrine insufficiency (PEI).
Regulation (affects) of GLP-1 associated with chronic pancreatitis
11) Confidence 0.11 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16954337 Disease Relevance 0.42 Pain Relevance 0.34
Infusion of atropine (10(-6) M) had no effect on the SP-induced GLP-1 release, but partly inhibited the effect of SP on somatostatin and VIP release, and the effect of NKA on VIP release.
Neg (no) Regulation (effect) of GLP-1 associated with somatostatin and substance p
12) Confidence 0.07 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10489905 Disease Relevance 0 Pain Relevance 0.86

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