INT184

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1977
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.54
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ephx1) enzyme binding (Ephx1)
Ephx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 40 100.00 Very High Very High Very High
dexamethasone 1 95.80 Very High Very High Very High
Paracetamol 3 93.84 High High
alcohol 1 93.04 High High
Chronic pancreatitis 1 89.44 High High
Morphine 3 86.36 High High
Disease Link Frequency Relevance Heat
Pancreatitis 3 97.64 Very High Very High Very High
Injury 2 95.48 Very High Very High Very High
Nicotine Addiction 1 94.12 High High
Adenocarcinoma 1 90.84 High High
Hepatotoxicity 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparisons between the responses of mEH, UGT and glutathione S-transferase (GST) activities were made. mEH activity was increased by beta-naphthoflavone, isosafrole, phenobarbital and clofibric acid.
Regulation (responses) of mEH
1) Confidence 0.60 Published 1996 Journal Toxicol. Lett. Section Abstract Doc Link 8619256 Disease Relevance 0 Pain Relevance 0.20
Gonadectomy altered the effect of methadone on epoxide hydratase, but not on aryl hydrocarbon hydroxylase activity, in both sexes.
Neg (not) Regulation (altered) of hydratase associated with methadone
2) Confidence 0.47 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.51
The glutathione S-transferase and aryl hydrocarbon hydroxylase activities were decreased in castrated male rats, whereas epoxide hydratase activity was unaltered.
Regulation (unaltered) of hydratase
3) Confidence 0.47 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.54
We studied the role of the EPHX1 c.337T>C (p.Y113H) variant, whichleads to altered enzyme activity, in pancreatic diseases.
Regulation (role) of EPHX1 associated with pancreatitis
4) Confidence 0.27 Published 2009 Journal Pancreas Section Abstract Doc Link 19287329 Disease Relevance 0.45 Pain Relevance 0.14
The effects of gonadectomy on the hepatic activities of aryl hydrocarbon hydroxylase, epoxide hydratase, and glutathione S-transferase in Wistar rats pretreated with oral methadone .
Regulation (effects) of hydratase associated with methadone
5) Confidence 0.21 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 445229 Disease Relevance 0 Pain Relevance 0.50
In contrast, in female rats it raised aryl hydrocarbon hydroxylase with no change in epoxide hydratase activity.
Neg (no) Regulation (change) of hydratase
6) Confidence 0.21 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.49
Gonadectomy altered the effect of methadone on epoxide hydratase, but not on aryl hydrocarbon hydroxylase activity, in both sexes.
Regulation (effect) of hydratase associated with methadone
7) Confidence 0.21 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.51
No change was seen in epoxide hydrase activity.
Neg (No) Regulation (change) of epoxide hydrase
8) Confidence 0.19 Published 1977 Journal Drug Metab. Dispos. Section Abstract Doc Link 15816 Disease Relevance 0 Pain Relevance 0.22
Changes in microsomal epoxide hydrolase activity showed high correlation (r = 0.97) with changes in UDP-glucuronosyltransferase (4-nitrophenol) activity.
Regulation (Changes) of microsomal epoxide hydrolase
9) Confidence 0.17 Published 1993 Journal Xenobiotica Section Abstract Doc Link 8498089 Disease Relevance 0 Pain Relevance 0.07
By comparison, the effects of allylthiobenzimidazole (ATB) on the levels of several hepatic cytochrome P450, microsomal epoxide hydrolase (mEH) and GST expression have been studied in the rat herein. 2.
Regulation (effects) of microsomal epoxide hydrolase
10) Confidence 0.06 Published 1998 Journal Xenobiotica Section Abstract Doc Link 9574820 Disease Relevance 0.10 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox