INT184006

Context Info Confidence 0.71 First Reported 2005 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 21 Total Number 22 Disease Relevance 7.97 Pain Relevance 1.86

extracellular space (Ighg2b)

Anatomy Link Frequency poly 3 B cells 2 lymph nodes 1 plasma 1 plasma cells 1 Ighg2b (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 218 100.00 chemokine 44 99.82 rheumatoid arthritis 165 99.30 agonist 113 97.96 Arthritis 215 97.12 Inflammation 203 96.80 fibrosis 2 83.36 imagery 38 75.56 cINOD 2 64.88 Crohn's disease 1 47.04

Disease Link Frequency Relevance Heat Infection 182 99.84 Arthropathy 1 99.68 Rheumatoid Arthritis 168 99.30 Arthritis 219 97.12 INFLAMMATION 224 96.80 Melanoma 7 95.92 Sprains And Strains 91 95.68 Adenoma 1 94.72 Disease 163 93.92 Immunization 312 93.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

+ IgG2c–expressing ASCs within extrafollicular foci.

Gene_expression (expressing) of IgG2c

1) Confidence 0.71 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.05 Pain Relevance 0

Heightened production of IgG2c is significant, as this isotype is the most efficient IgG subclass for anti-pathogen FcR-mediated effector functions (Nimmerjahn and Ravetch, 2005) and has long been recognized as the predominant isotype elicited by viral infections (Coutelier et al., 1987).

Gene_expression (production) of IgG2c associated with viral infection

2) Confidence 0.71 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.09 Pain Relevance 0

, PE conjugated; Biolegend, San Diego, CA, USA) and CXCR4 (2B11/CXCR4, rat IgG2b ?

Gene_expression (/) of IgG2b

3) Confidence 0.65 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.14

200, clone HIS24, mouse IgG2b, BD Biosciences), anti-mouse Mac3 (1?

Gene_expression (clone) of IgG2b

4) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440803 Disease Relevance 0 Pain Relevance 0

Briefly, mouse monoclonal antihuman C-C chemokine ligand-2/MCP-1 IgG2b (R&D Systems) was coated onto polystyrene microtitre plates (Nunc-Immunoplate II; BRL, Uxbridge, Middlesex, UK) at a concentration of 2 ?

Gene_expression (/) of IgG2b associated with chemokine

5) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246249 Disease Relevance 0 Pain Relevance 0.13

The IgG2b anti-murine RAGE mAb was developed by Wyeth (Cambridge, MA, USA).

Gene_expression (anti) of IgG2b

6) Confidence 0.65 Published 2007 Journal Crit Care Section Body Doc Link PMC2246216 Disease Relevance 0.51 Pain Relevance 0

For each set, appropriate isotypic control was done (IgG2b,?

Gene_expression (done) of IgG2b

7) Confidence 0.65 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 0.08 Pain Relevance 0

In this paper, we show that TLR agonists significantly enhance the TI-2 antibody response through the elaboration of type I IFN that promotes production of IgG2c by FO B cells.

Gene_expression (production) of IgG2c in B cells associated with agonist

8) Confidence 0.55 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0 Pain Relevance 0.05

These findings strongly suggest that FO B cells are the predominant source of the poly(I:C)-induced IgG2c antibody response to the TI-2 antigen NP-Ficoll.

Gene_expression (source) of IgG2c in poly

9) Confidence 0.55 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.22 Pain Relevance 0

S1 shows dose response of poly(I:C) on the production of NP-specific IgG2c and lack of polyclonal IgG2c production.

Gene_expression (production) of IgG2c in poly

10) Confidence 0.55 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0 Pain Relevance 0.03

S1 shows dose response of poly(I:C) on the production of NP-specific IgG2c and lack of polyclonal IgG2c production.

Gene_expression (production) of IgG2c in poly

11) Confidence 0.55 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0 Pain Relevance 0.03

Collectively, our findings suggest that in the presence of poly(I:C), a B cell population distinct from MZ B cells is the predominant source of NP-specific IgG2c.

Gene_expression (source) of IgG2c in B cells

12) Confidence 0.55 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.24 Pain Relevance 0

+ plasma cells that lacked IgM or IgG2c expression (Fig. 2 B) were also observed with poly(I:C) and are likely to be NP-specific IgG3-producing ASCs, as this isotype comprised a significant amount of the response (Fig. 1 B).

Gene_expression (expression) of IgG2c in plasma cells

13) Confidence 0.55 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0 Pain Relevance 0

The NP-specific mAb S43-10 (Reth et al., 1978) was used as a positive control for a high-affinity NP-specific IgG2c antibody with an affinities of Kd = 2.4 × 10?

Gene_expression (antibody) of IgG2c

14) Confidence 0.54 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.05 Pain Relevance 0

Later in the course of infection, (day 35–40 post-infection) IgG1, IGg2b, IgG3, and IgA were produced.

Gene_expression (produced) of IGg2b associated with infection

15) Confidence 0.49 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 1.28 Pain Relevance 0

A mouse line of mutated gp130 in which the SHP-2/SOCS3-binding site was disrupted developed a RA-like joint disease with increased production of Th1-type cytokines and immunoglobulins of the IgG2a and IgG2b classes [78].

Gene_expression (production) of IgG2b in joint associated with rheumatoid arthritis, arthropathy and cytokine

16) Confidence 0.49 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.43 Pain Relevance 0.53

However, antigen-specific IgG2c ASCs were also present in the lymph nodes of mice immunized with NP-Ficoll + poly(I:C) and were virtually absent in mice immunized with antigen alone (Fig. 3 B).

Neg (absent) Gene_expression (present) of IgG2c in lymph nodes

17) Confidence 0.48 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.16 Pain Relevance 0

For granulocyte depletion studies, GR-1 or control antibody (IgG2b) at 300 µg/mouse (Biolegend, San Diego, CA) was administered intraperitoneally two days prior to B16-BL6 melanoma implantation in PPAR?

Gene_expression (at) of IgG2b in granulocyte associated with melanoma

18) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.11 Pain Relevance 0

RIII-deficient DBA/1 mice were almost completely protected from arthritogenic IgG1, IgG2a or IgG2b antibodies, indicating that activating Fc?

Gene_expression (antibodies) of IgG2b

19) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.50 Pain Relevance 0.52

The plasma levels of IgM, IgG1, IgG2a, IgG2b, IgG3, and IgA were determined simultaneously in the same sample using a bead-based assay with monoclonal anti-mouse antibodies conjugated to beads of different color regions (Biorad, USA), and acquired on a Bioplex reader (Biorad).

Spec (determined) Gene_expression (levels) of IgG2b in plasma

20) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.07 Pain Relevance 0

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