INT184009

Context Info Confidence 0.35 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.22 Pain Relevance 0.20

plasma membrane (Cish)

Cish (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 10 92.88 cytokine 50 90.48 Hippocampus 9 76.68 Inflammation 34 47.12 Catechol-O-methyltransferase 27 5.00 Dopamine 15 5.00 Nucleus accumbens 5 5.00 Neurotransmitter 5 5.00 Catecholamine 4 5.00 Arthritis 4 5.00

Disease Link Frequency Relevance Heat Sprains And Strains 57 99.88 Cancer 13 94.92 Rheumatoid Arthritis 10 92.88 Obesity 3 83.36 Diabetes Mellitus 2 82.88 Reprotox - General 1 1 82.12 Hyperlipidemia 1 76.40 Lung Cancer 1 58.56 T-cell Lymphoma 1 50.92 Blast Crisis 1 50.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The reduction of SOCS expression is also a therapeutic target. siRNA technology made the reduction of SOCS1 expression in DCs possible, and also improved anti-tumor immunity [69].

Negative_regulation (reduction) of Gene_expression (expression) of SOCS associated with cancer

1) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.73 Pain Relevance 0.16

All crosses derived from strains that differed in Comt expression show strong cis-modulation.

Negative_regulation (differed) of Gene_expression (expression) of cis-modulation associated with sprains and strains

2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.49 Pain Relevance 0.04

General Comments

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