INT18401

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Context Info
Confidence 0.47
First Reported 1984
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.29
Pain Relevance 5.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
neurons 4
neural 2
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 85 100.00 Very High Very High Very High
Somatostatin 79 100.00 Very High Very High Very High
depression 60 100.00 Very High Very High Very High
Dopamine 16 99.76 Very High Very High Very High
tetrodotoxin 19 98.30 Very High Very High Very High
gABA 9 97.48 Very High Very High Very High
Glutamate receptor 1 97.04 Very High Very High Very High
antagonist 4 96.28 Very High Very High Very High
Neurotransmitter 1 94.68 High High
Glutamate 2 93.72 High High
Disease Link Frequency Relevance Heat
Depression 60 100.00 Very High Very High Very High
Bordatella Infection 1 60.36 Quite High
Sprains And Strains 1 60.00 Quite High
Li-fraumeni Syndrome 3 39.96 Quite Low
Convulsion 1 34.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the prolonged activation of somatostatin receptors induces the desensitization of somatostatin-induced inhibition on low [Mg(2+)](o)-induced [Ca(2+)](i) spikes through the activation of GRK2 and partly a novel PKCepsilon in cultured rat hippocampal neurons.
Positive_regulation (induces) of Positive_regulation (activation) of somatostatin in neurons associated with somatostatin
1) Confidence 0.47 Published 2006 Journal Brain Res. Section Abstract Doc Link 16879804 Disease Relevance 0.06 Pain Relevance 0.56
Metoclopramide (10 mumol/l) blocked the dopamine (1 mumol/l)-induced increase in somatostatin release.
Positive_regulation (-induced) of Positive_regulation (increase) of somatostatin associated with dopamine and somatostatin
2) Confidence 0.44 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 2864381 Disease Relevance 0 Pain Relevance 1.01
These results show that almost all the somatostatin response to bombesin is indirectly mediated, and is composed of a major neural (cholinergic) and a minor nonneural pathway.
Positive_regulation (mediated) of Positive_regulation (response) of somatostatin in neural associated with somatostatin
3) Confidence 0.43 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1976561 Disease Relevance 0 Pain Relevance 0.75
Dopamine (10 nmol/1-0.1 mmol/l) induced a progressive increase (r = 0.41; P less than 0.01) in basal somatostatin levels.
Positive_regulation (induced) of Positive_regulation (increase) of somatostatin associated with dopamine and somatostatin
4) Confidence 0.41 Published 1985 Journal J. Endocrinol. Section Abstract Doc Link 2864381 Disease Relevance 0 Pain Relevance 0.84
Cholinergic mediation of gamma-aminobutyric acid-induced gastrin and somatostatin release from rat antrum.
Positive_regulation (mediation) of Positive_regulation (acid-induced) of somatostatin associated with somatostatin
5) Confidence 0.40 Published 1986 Journal Gastroenterology Section Title Doc Link 2875917 Disease Relevance 0 Pain Relevance 0.62
The increased levels of somatostatin (peptide and mRNA) induced by NTs were not blocked by tetrodotoxin or by glutamate receptor antagonists, suggesting that endogenous neurotransmitters (e.g. glutamate) were not involved in these effects.
Positive_regulation (increased) of Positive_regulation (increased) of somatostatin associated with tetrodotoxin, glutamate, neurotransmitter, antagonist, glutamate receptor and somatostatin
6) Confidence 0.33 Published 1999 Journal Endocrinology Section Abstract Doc Link 9927323 Disease Relevance 0 Pain Relevance 0.78
GLP-1 (7-36) amide-induced inhibition of gastric acid secretion may, at least in part, be due to enhanced somatostatin and/or decreased gastrin release.
Spec (may) Positive_regulation (due) of Positive_regulation (enhanced) of somatostatin associated with somatostatin
7) Confidence 0.32 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 1972810 Disease Relevance 0 Pain Relevance 0.37
Both these responses were abolished by addition of the axonal blocker, tetrodotoxin (10(-6) M), to the vascular perfusate, from which it was concluded that gastrin and somatostatin responses induced by peptone were mediated by intramural neurons.
Positive_regulation (mediated) of Positive_regulation (induced) of somatostatin in neurons associated with tetrodotoxin and somatostatin
8) Confidence 0.32 Published 1984 Journal Gastroenterology Section Abstract Doc Link 6146551 Disease Relevance 0 Pain Relevance 0.31
In rat fundic segments, superfusion with adrenomedullin (0.1 pM to 0.1 microM) caused a concentration-dependent increase in somatostatin secretion (EC(50), 1 x 10(-10)) that was accompanied by a reciprocal decrease in histamine secretion (EC(50), 1.2 x 10(-11)).
Positive_regulation (caused) of Positive_regulation (increase) of somatostatin associated with somatostatin
9) Confidence 0.28 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12573799 Disease Relevance 0 Pain Relevance 0.28
To induce LTP or LTD, sequential stimulation (SSt) that consisted of 600 pulses at 5 Hz, or at 1 and 10 Hz was delivered to ipsilateral Schaffer and contralateral commissural pathways with stimulation timing between both inputs indicated by the inter-peak intervals (?
Positive_regulation (induce) of Positive_regulation (stimulation) of SSt associated with depression and long-term potentiation
10) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2475662 Disease Relevance 0.23 Pain Relevance 0.17

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