INT184015

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.32
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat5a) nucleus (Stat5a) DNA binding (Stat5a)
cytoplasm (Stat5a) signal transducer activity (Stat5a)
Anatomy Link Frequency
spleens 1
Stat5a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 222 99.88 Very High Very High Very High
Inflammation 185 82.80 Quite High
addiction 2 60.28 Quite High
Glutamate receptor 3 57.04 Quite High
Bioavailability 3 39.76 Quite Low
opioid receptor 1 26.56 Quite Low
fibrosis 9 19.28 Low Low
cva 4 17.68 Low Low
Multiple sclerosis 316 5.00 Very Low Very Low Very Low
Central nervous system 54 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 44 99.84 Very High Very High Very High
Cancer 246 94.32 High High
Autoimmune Disease 95 94.24 High High
Apoptosis 57 93.96 High High
Metastasis 10 92.48 High High
INFLAMMATION 194 82.80 Quite High
Repression 22 82.60 Quite High
Skin Cancer 59 74.40 Quite High
Pathologic Processes 7 66.36 Quite High
Targeted Disruption 55 61.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CIS is induced by cytokines that activate STAT5 and bind to receptors that activate STAT5, namely erythropoietin, IL-2, IL-3, prolactin and growth hormone (GH) [11].
Positive_regulation (activate) of STAT5 associated with cytokine
1) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.12 Pain Relevance 0.17
There was constitutive activation of Stat5 and detectable expression of the Stat5 target Bcl-XL in BM of both normal and polycythemic mice, with increased Stat5 phosphorylation and Bcl-XL in spleens from JAKV617F recipients, although this could in part reflect the increase in splenic myeloerythroid cells in these mice.
Positive_regulation (activation) of Stat5 in spleens
2) Confidence 0.36 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.10 Pain Relevance 0
Competition or steric hindrance for binding sites that are used to recruit and activate STATs (especially STAT5) has been proposed as the mechanism by which CIS and SOCS2 inhibit cytokine signaling [11,12].
Positive_regulation (activate) of STAT5 associated with cytokine
3) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.13 Pain Relevance 0.20
CIS is induced by cytokines that activate STAT5 and bind to receptors that activate STAT5, namely erythropoietin, IL-2, IL-3, prolactin and growth hormone (GH) [11].
Positive_regulation (activate) of STAT5 associated with cytokine
4) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.11 Pain Relevance 0.17
miR-155 deficiency in Treg cells results in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of IL-2.
Positive_regulation (activation) of STAT5 associated with cytokine
5) Confidence 0.27 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.23 Pain Relevance 0.08
miR-155 deficiency in Treg cells results in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of IL-2.
Positive_regulation (activation) of signal transducer and activator of transcription 5 associated with cytokine
6) Confidence 0.27 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.23 Pain Relevance 0.08
Network 9 (Figure 6) has IL-6, STAT5, and SRC in a central position.
Positive_regulation (has) of STAT5
7) Confidence 0.22 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.26 Pain Relevance 0.11
Moreover curcumin suppresses the activation of several transcription factors that are implicated in carcinogenesis: it suppresses the activation of nuclear factor kappa B (NFkB), activator protein 1 (AP-1), and at least two of the signal transducer and activator of transcription proteins (STAT3, STAT5).
Positive_regulation (activation) of STAT5
8) Confidence 0.15 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.38 Pain Relevance 0.06
They found higher levels of activated STAT1, STAT3, and STAT5 in lymphoma cell lines that poorly responded to Vorinostat treatment compared to sensitive cell lines.
Positive_regulation (levels) of STAT5 associated with lymphatic system cancer
9) Confidence 0.13 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.38 Pain Relevance 0
They found higher levels of activated STAT1, STAT3, and STAT5 in lymphoma cell lines that poorly responded to Vorinostat treatment compared to sensitive cell lines.
Positive_regulation (activated) of STAT5 associated with lymphatic system cancer
10) Confidence 0.13 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.38 Pain Relevance 0

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