INT184017

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Context Info
Confidence 0.63
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.47
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Socs1)
Anatomy Link Frequency
macrophage 2
B cells 2
Socs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 193 100.00 Very High Very High Very High
tolerance 92 94.20 High High
metalloproteinase 3 85.12 High High
Inflammation 155 71.80 Quite High
addiction 3 63.80 Quite High
Multiple sclerosis 158 5.00 Very Low Very Low Very Low
rheumatoid arthritis 32 5.00 Very Low Very Low Very Low
Central nervous system 27 5.00 Very Low Very Low Very Low
imagery 13 5.00 Very Low Very Low Very Low
Arthritis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 123 98.84 Very High Very High Very High
Targeted Disruption 46 97.92 Very High Very High Very High
Autoimmune Disease 49 97.76 Very High Very High Very High
B-cell Lymphoma 3 95.20 Very High Very High Very High
Leukemia 5 89.60 High High
Repression 9 86.12 High High
Chronic Myeloid Leukemia 3 82.64 Quite High
Hematologic Neoplasms 3 81.64 Quite High
Hepatocellular Cancer 27 78.20 Quite High
Blast Crisis 3 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In most cases, SOCS1 overexpression in cell lines could inhibit tumor cell proliferation; SOCS1 could therefore be an important target of anti-tumor therapy.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SOCS1 associated with cancer
1) Confidence 0.63 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.45 Pain Relevance 0.03
However, Gingras and colleagues [64] did not observe enhanced LPS responses in SOCS1-deficient bone marrow-derived macrophages cultured with macrophage colony-stimulating factor (M-CSF).
Neg (not) Positive_regulation (enhanced) of Gene_expression (responses) of SOCS1 in macrophage
2) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.19 Pain Relevance 0.18
We generated mice in which SOCS1 expression was restored in T and B cells on a SOCS1-/- background (SOCS1-/-transgenic mice).
Positive_regulation (restored) of Gene_expression (expression) of SOCS1 in B cells associated with targeted disruption
3) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.22 Pain Relevance 0.08
miR-155 deficiency in Treg cells results in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of IL-2.
Positive_regulation (increased) of Gene_expression (expression) of cytokine signaling 1 associated with cytokine
4) Confidence 0.27 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.24 Pain Relevance 0.08
Most conspicuous is activation of the Jak/Stat pathway as indicated by elevated expression of Jak2 and Stat1, decreased expression of Socs1 and increased expression of several Stat target genes (Myc, Irf1, Igsf3g and Usp20) (Fig. 11A).
Positive_regulation (increased) of Gene_expression (expression) of Socs1
5) Confidence 0.20 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.25 Pain Relevance 0.11
To test this hypothesis, PKR was overexpressed in HEK293T cells, along with increasing concentrations of a SOCS-1 expression vector.
Positive_regulation (increasing) of Gene_expression (expression) of SOCS-1
6) Confidence 0.15 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.06 Pain Relevance 0.13
PKR was immunoprecipitated only in the presence of cotransfected SOCS-1 (Fig. 5D, top).
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of SOCS-1
7) Confidence 0.11 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.06 Pain Relevance 0

General Comments

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