INT184020

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.05
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) cytoplasm (Socs3)
Socs3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 98 100.00 Very High Very High Very High
Arthritis 112 98.14 Very High Very High Very High
fibrosis 4 96.00 Very High Very High Very High
cytokine 90 89.60 High High
rheumatoid arthritis 64 87.32 High High
cINOD 5 79.76 Quite High
Crohn's disease 3 61.04 Quite High
Inflammatory response 2 44.72 Quite Low
metalloproteinase 7 18.28 Low Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 95 100.00 Very High Very High Very High
Disease 38 100.00 Very High Very High Very High
Cancer 31 99.76 Very High Very High Very High
Inflammatory Bowel Disease 11 99.14 Very High Very High Very High
Arthritis 118 98.14 Very High Very High Very High
Colorectal Cancer 34 97.74 Very High Very High Very High
Cirrhosis 1 96.00 Very High Very High Very High
Infection 3 92.44 High High
Hepatitis C Virus Infection 1 92.04 High High
Hepatitis 5 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, while our results could indicate that SOCS3 is more important in the underlying pathogenesis of inflammation-associated rather than sporadic CRC, recent studies comparing SOCS3 expression in both ulcerative colitis-associated and sporadic tumors found that SOCS3 was decreased and there was no significant difference between the two groups for SOCS3 [2].
Localization (decreased) of SOCS3 associated with colorectal cancer, inflammatory bowel disease, inflammation and cancer
1) Confidence 0.75 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 0.98 Pain Relevance 0.05
SOCS3 mRNA abundance was determined using the ABI Prism 7900 HT (Applied Biosystems, Foster City, CA) and Platinum Quantitative PCR SuperMix-UDG (Invitrogen, Carlsbad, CA).
Localization (abundance) of SOCS3 mRNA
2) Confidence 0.75 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 0.49 Pain Relevance 0.12
SOCS3 and inflammatory diseases
Localization (diseases) of SOCS3 associated with inflammation and disease
3) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.85 Pain Relevance 0.60
Other molecules that have been demonstrated to play a role in arthritis using gene transfer in various in vitro or animal models are Csk, cathepsin L, fibronectin, galectin-1, p16INK4A, p21Cip1, SOCS3, soluble CR1, superoxide dismutase and catalase, Ras, and prothymosin ?
Localization (galectin-1) of SOCS3 associated with arthritis
4) Confidence 0.08 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 0.73 Pain Relevance 0.29

General Comments

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