INT184022

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.79
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cish)
Cish (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 88 98.92 Very High Very High Very High
Inflammation 61 86.72 High High
tolerance 15 85.52 High High
Hippocampus 18 76.68 Quite High
Inflammatory response 13 74.96 Quite High
Catechol-O-methyltransferase 54 5.00 Very Low Very Low Very Low
Dopamine 30 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Nucleus accumbens 10 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 115 99.88 Very High Very High Very High
Lyme Disease 13 91.12 High High
Syndrome 2 90.08 High High
Lymphopenia 1 87.44 High High
INFLAMMATION 72 86.72 High High
Hepatotoxicity 1 81.84 Quite High
Targeted Disruption 12 77.28 Quite High
Disease 32 75.20 Quite High
Infection 5 62.56 Quite High
Non-genital Cutaneous Warts 1 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These are consistent with our initial proposal that CIS is a negative regulator of STAT5 [11].
Negative_regulation (regulator) of CIS
1) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.48 Pain Relevance 0.04
The persistence of strong cis-modulation in the absence of SNPs provided a unique opportunity to identify the cryptic, but causal sequence variant in Comt.


Negative_regulation (persistence) of cis-modulation
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.43 Pain Relevance 0.03
All crosses derived from strains that differed in Comt expression show strong cis-modulation.
Negative_regulation (differed) of cis-modulation associated with sprains and strains
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.49 Pain Relevance 0.04
We provide evidence that reduced SOCS activity licenses greater cytokine production through diminished negative regulation of the TLR2 pathway.
Negative_regulation (reduced) of SOCS associated with cytokine
4) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.39 Pain Relevance 0.38

General Comments

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