INT184023

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.75
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Jak2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 68 96.32 Very High Very High Very High
cytokine 100 50.00 Quite Low
rheumatoid arthritis 20 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
B-cell Lymphoma 2 97.92 Very High Very High Very High
INFLAMMATION 62 96.32 Very High Very High Very High
Disease 40 95.80 Very High Very High Very High
Leukemia 2 92.32 High High
Cancer 26 91.92 High High
Hematologic Neoplasms 2 84.36 Quite High
Hepatocellular Cancer 18 80.92 Quite High
Chronic Myeloid Leukemia 2 76.88 Quite High
Non-genital Cutaneous Warts 2 76.24 Quite High
Solid Tumor 2 75.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mutations probably result in impaired JAK2 degradation and sustained JAK2 activation [94].
Protein_catabolism (degradation) of JAK2
1) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.49 Pain Relevance 0.04
The importance of the SOCS box has been recognized from the following evidence: the SOCS box of SOCS1 is necessary for the suppression of the oncogenic activity of TEL-JAK2 by SOCS1 [27,28] as well as for the degradation of wild-type activated JAK2 [29], and mice that were genetically modified to lack only the SOCS box of SOCS1 exhibited inflammatory diseases similar to complete SOCS1-deficient mice with slower onsets [30].
Protein_catabolism (degradation) of JAK2 associated with inflammation and disease
2) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.27 Pain Relevance 0.05

General Comments

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