INT184027

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Context Info
Confidence 0.82
First Reported 2005
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.58
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Anatomy Link Frequency
spleen 1
mast cells 1
Jak2 (Mus musculus)
Jak2 - V617F (1)
Pain Link Frequency Relevance Heat
agonist 69 98.72 Very High Very High Very High
cytokine 211 94.08 High High
Inflammation 131 73.28 Quite High
Multiple sclerosis 31 71.68 Quite High
rheumatoid arthritis 11 71.04 Quite High
tolerance 2 64.64 Quite High
Central nervous system 67 57.36 Quite High
Pain 17 53.84 Quite High
Cannabinoid receptor 5 50.00 Quite Low
cva 1 32.08 Quite Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 46 96.36 Very High Very High Very High
Reprotox - General 1 1 93.60 High High
Apoptosis 26 92.44 High High
Disease 111 86.80 High High
Cancer 30 83.64 Quite High
Autoimmune Disease 7 83.04 Quite High
Lung Cancer 1 81.52 Quite High
Infection 397 79.32 Quite High
T-cell Lymphoma 1 73.88 Quite High
INFLAMMATION 153 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was constitutive activation of JAK2 V617F in BM and spleen cells, as evidenced by phosphorylation at the activation loop tyrosines 1007 and 1008, whereas JAK2 WT was not detectably phosphorylated.
Neg (not) Phosphorylation (phosphorylated) of JAK2 (V617F) in spleen
1) Confidence 0.82 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0 Pain Relevance 0
Bulanova et al. [25] have shown that addition of extracellular ATP in the millimolar range induced activation of P2X7 expressed on murine mast cells, resulting in the rapid but transient phosphorylation of ERK, Jak2 and STAT6.
Phosphorylation (phosphorylation) of Jak2 in mast cells
2) Confidence 0.51 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.65 Pain Relevance 0.24
For phosphorylation of JAK1 and JAK2, membranes were first hybridized with phospho-specific Tyr1022/1023 JAK1 or Tyr1007/1008 JAK2 antibody (Cell Signaling Technology, Beverly, MA) and then stripped and finally analyzed by total JAK1 or JAK2 antibody.
Spec (analyzed) Phosphorylation (phosphorylation) of JAK2
3) Confidence 0.47 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.07
IL-12-induced tyrosine phosphorylation of Jak2, Tyk2, Stat3, and Stat4 in T
Phosphorylation (phosphorylation) of Jak2
4) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.74 Pain Relevance 0.21
This 12-mer peptide interacts specifically with the autophosphorylation site of JAK2 and inhibits IFN-?
Phosphorylation (autophosphorylation) of JAK2
5) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.78 Pain Relevance 0.07
to the receptor complex, JAK2 autophosphorylates and then transphosphorylates JAK1.
Phosphorylation (transphosphorylates) of JAK2
6) Confidence 0.24 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.20 Pain Relevance 0.14
to the receptor complex, JAK2 autophosphorylates and then transphosphorylates JAK1.
Phosphorylation (autophosphorylates) of JAK2
7) Confidence 0.24 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.20 Pain Relevance 0.14

General Comments

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