INT184030

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.54
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 2
stem 1
Socs2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 77 100.00 Very High Very High Very High
depression 26 94.04 High High
tolerance 86 92.80 High High
Inflammation 60 78.48 Quite High
gABA 51 74.24 Quite High
ischemia 23 68.96 Quite High
GABAergic 3 61.96 Quite High
agonist 7 59.80 Quite High
palliative 6 50.00 Quite Low
Neurotransmitter 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 10 99.08 Very High Very High Very High
Manic Depressive Disorder 6 97.72 Very High Very High Very High
Disease 44 96.88 Very High Very High Very High
Darier's Disease 2 96.48 Very High Very High Very High
Depression 30 94.04 High High
Hypertrophy 2 89.92 High High
Body Weight 4 87.64 High High
Bronchopulmonary Dysplasia 2 87.00 High High
Starvation 2 84.32 Quite High
Targeted Disruption 64 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only two candidates near or within this locus are expressed in the brain: Socs2, which is involved in neurogenesis, and Nudt4/Dipp2, which regulates phosphatase signaling in the brain.
Gene_expression (expressed) of Socs2 in brain associated with neurodegenerative disease
1) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012073 Disease Relevance 1.22 Pain Relevance 0.09
In order to identify candidate genes, we genotyped all known SNPs and resequenced the coding regions of the brain-expressed candidate quantitative genes Tmem108 (NM_178638.3), Socs2 (NM_007706.3), and Nudt4 (NM_027722), located in or near the two significant TST loci.
Gene_expression (expressed) of Socs2 in brain
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012073 Disease Relevance 0.37 Pain Relevance 0
This sequence of molecular events is associated with a marked induction of SOCS1, SOCS2, SOCS3, as well as cytokine-induced Src homology 2-containing protein expression.
Gene_expression (expression) of SOCS2 associated with cytokine
3) Confidence 0.43 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.15 Pain Relevance 0.09
Expression of SOCS2 is not directly induced by IGF-1 but is directly induced by GH.
Gene_expression (Expression) of SOCS2
4) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.62 Pain Relevance 0.04
Some studies discovered that EPO enhanced the expression of a signaling protein (SOCS2) and a transcriptional factor (neurogenin 1) to regulate the neural stem/progenitor cell proliferation and differentiation [35], [37].
Gene_expression (expression) of SOCS2 in stem
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.40 Pain Relevance 0.18
Importantly, SOCS-2 overexpression had a negligible effect on the basal level of PKR, even at the highest dose (Fig. 5C).
Gene_expression (overexpression) of SOCS-2
6) Confidence 0.09 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0
Expression plasmids for FLAG-tagged SOCS-1 and SOCS-2 were kind gifts from Raymond Donnelly (FDA, Bethesda, MD).


Gene_expression (Expression) of SOCS-2
7) Confidence 0.07 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0.08
A similar process occurs for the GHB derivative, D-2-HG (Fig. 2).
Gene_expression (derivative) of D-2-HG
8) Confidence 0.04 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.13 Pain Relevance 0.10
Fgf21 also induces the hepatic expression of genes encoding IGF-1-binding protein 1 and suppressor of cytokine signaling 2, which blunt growth hormone signaling (Inagaki et al. 2008).
Gene_expression (expression) of cytokine signaling 2 associated with cytokine
9) Confidence 0.03 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.65 Pain Relevance 0.05

General Comments

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