INT184031

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 21
Disease Relevance 9.82
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cish)
Anatomy Link Frequency
proximal 2
myocardium 1
B cell 1
brain 1
Cish (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 224 100.00 Very High Very High Very High
rheumatoid arthritis 30 99.28 Very High Very High Very High
Catechol-O-methyltransferase 250 98.52 Very High Very High Very High
Glutamate receptor 23 98.40 Very High Very High Very High
Inflammatory response 20 97.52 Very High Very High Very High
Inflammation 244 95.52 Very High Very High Very High
Dopamine 122 91.60 High High
addiction 24 91.08 High High
long-term potentiation 9 82.00 Quite High
Arthritis 14 80.48 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 694 99.54 Very High Very High Very High
Rheumatoid Arthritis 30 99.28 Very High Very High Very High
Disease 123 98.24 Very High Very High Very High
Cognitive Disorder 53 97.88 Very High Very High Very High
Leukemia 3 97.72 Very High Very High Very High
B-cell Lymphoma 3 97.60 Very High Very High Very High
INFLAMMATION 256 97.52 Very High Very High Very High
Neurodegenerative Disease 20 95.64 Very High Very High Very High
Cancer 42 94.92 High High
Injury 9 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction of SOCS expression is also a therapeutic target. siRNA technology made the reduction of SOCS1 expression in DCs possible, and also improved anti-tumor immunity [69].
Gene_expression (expression) of SOCS associated with cancer
1) Confidence 0.49 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.68 Pain Relevance 0.16
The generation of SOCS proteins carrying membrane-permeable peptide by genetic engineering might be another way to introduce JAK inhibitor into specific cells.
Gene_expression (generation) of SOCS
2) Confidence 0.49 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.77 Pain Relevance 0.13
Interestingly, biallelic mutation in the SOCS box of the SOCS1 gene was found in 9 of 20 primary mediastinal B cell lymphoma cells.
Gene_expression (box) of SOCS in B cell associated with b-cell lymphoma
3) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.45 Pain Relevance 0.04
Collectively, these diverse mapping data sets demonstrate that expression of Comt is strongly cis-regulated and is caused by sequence variation in or around Comt itself.
Gene_expression (expression) of cis-regulated
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.46 Pain Relevance 0.03
All crosses derived from strains that differed in Comt expression show strong cis-modulation.
Gene_expression (expression) of cis-modulation associated with sprains and strains
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.49 Pain Relevance 0.04
The cause of this Comt cis-regulation is the insertion of a strong and premature polyadenylation signal in the proximal 3?
Gene_expression (this) of cis in proximal
6) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.86 Pain Relevance 0.12
The cause of this Comt cis-regulation is the insertion of a strong and premature polyadenylation signal in the proximal 3?
Gene_expression (cause) of cis in proximal
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.86 Pain Relevance 0.12
Variation in Comt mRNA expression and cis-regulation in CNS and peripheral tissues
Gene_expression (expression) of cis
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.80 Pain Relevance 0.09
In this study we have identified the sequence variant underlying a strong cis-acting expression quantitative trait locus (eQTL) for the Comt gene.
Gene_expression (expression) of cis-acting
9) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.31 Pain Relevance 0.12
In contrast, expression of more proximal coding exons (probe set 1449183_at) is not as strongly cis-regulated, is more variable across brain regions and organs, and is usually associated with higher expression from the B6 (B) allele (Fig. 1B).
Gene_expression (expression) of cis-regulated in brain
10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.19 Pain Relevance 0
For this reason we closely examined this variant to understand the mechanisms that generate the strong cis eQTL.


Gene_expression (generate) of cis
11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.38 Pain Relevance 0.03
These stable states are defined by the regulatory interactions between the expressed SSTFs and the kernel-specific cis-regulatory modules of these expressed SSTFs.
Gene_expression (expressed) of cis
12) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
The regions identified delimit likely locations of cis and trans acting factors that affect that gene’s expression and are termed expression QTLs, or eQTLs (Bystrykh et al. 2005; Chesler et al. 2005; Hubner et al. 2005).
Gene_expression (expression) of cis
13) Confidence 0.24 Published 2006 Journal Mamm Genome Section Body Doc Link PMC2677977 Disease Relevance 0.46 Pain Relevance 0
The differential expression of three genes, Slc22a4, Pcsk2, and the clone BG075643, had significant linkage scores associated with markers near to their genomic locations and thus are potentially cis-regulated.
Gene_expression (expression) of cis
14) Confidence 0.24 Published 2006 Journal Mamm Genome Section Body Doc Link PMC2677977 Disease Relevance 0.57 Pain Relevance 0
is consistent with reduced SOCS expression observed in these cells.


Gene_expression (expression) of SOCS
15) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.62 Pain Relevance 0.13
Significant LRS close to transcript position, which is an indication of cis-acting variations (LRS > 32.2, LOD > 7), was found for Atp1a2 (1434893_at, LRS = 65.48 and 1455136_at, LRS = 121.4), Kcnj9 (1450712_at, LRS = 65.22), Comt (1418701_at, LRS = 59.20 and 1449183_at, LRS = 44.95) and Grm7 (1459532_at, LRS = 33.51).
Gene_expression (variations) of cis-acting associated with catechol-o-methyltransferase and glutamate receptor
16) Confidence 0.09 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.18 Pain Relevance 0.20
Differences in the signal of four genes (Atp1a2, Kcnj9, Grm7, Comt) selected for further investigation were found to be regulated by strong cis-acting elements.
Gene_expression (elements) of cis-acting associated with catechol-o-methyltransferase and glutamate receptor
17) Confidence 0.09 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.22 Pain Relevance 0.16
In addition, there was increased expression of the Suppression of Cytokine Signaling (SOCS), CD36, and PD-1L genes and others including C1q.
Gene_expression (expression) of SOCS associated with cytokine
18) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.40 Pain Relevance 0.13
Therefore, our studies in PO feline myocardium cannot rule out JAK2's contribution to STAT3 phosphorylation in the early period of PO,41 where it might be subsequently inactivated by the expression of SOCS, and under these conditions, other NTKs might sustain STAT3 activation.
Gene_expression (expression) of SOCS in myocardium
19) Confidence 0.02 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.05
Therefore, the competition between SMN2 cis-splicing and trans-splicing is likely reduced, providing a potential advantage to trans-splicing in the SMN context compared to other alternatively regulated exons that retain fully functional splice sites.
Gene_expression (cis-splicing) of cis-splicing
20) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.14 Pain Relevance 0

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