INT184032

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.08
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) cytoplasm (Socs3)
Anatomy Link Frequency
T cells 2
Socs3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 21 98.90 Very High Very High Very High
Inflammation 167 98.70 Very High Very High Very High
Inflammatory stimuli 3 98.48 Very High Very High Very High
cytokine 150 96.76 Very High Very High Very High
Arthritis 9 91.52 High High
cINOD 9 77.48 Quite High
Inflammatory response 13 67.00 Quite High
Inflammatory mediators 7 55.72 Quite High
fibrosis 7 39.36 Quite Low
Crohn's disease 5 31.60 Quite Low
Disease Link Frequency Relevance Heat
Stress 7 100.00 Very High Very High Very High
Eczema 2 99.92 Very High Very High Very High
Asthma 2 99.04 Very High Very High Very High
Rheumatoid Arthritis 21 98.90 Very High Very High Very High
INFLAMMATION 184 98.70 Very High Very High Very High
Disease 49 98.44 Very High Very High Very High
Hypersensitivity 4 98.08 Very High Very High Very High
Arthritis 13 92.32 High High
Targeted Disruption 36 91.68 High High
Cancer 59 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blood CD4+ T cells from patients with rheumatoid arthritis (RA) contained higher levels of SOCS1 but lower levels of SOCS3 mRNA than control CD4+ T cells, as determined by real-time polymerase chain reaction [73].
Regulation (control) of SOCS3 in T cells associated with rheumatoid arthritis
1) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.12 Pain Relevance 0.59
PPAR ligands can activate anti-inflammatory pathways both dependently and independently of IL-10, under the control of the negative regulatory influence of SOCS3.
Regulation (control) of SOCS3 associated with inflammation
2) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.34 Pain Relevance 0.12
SOCS3 mRNA up-regulation in the COX-2 deficient mice can thus be viewed as the consequence of the higher cytokine production in these mice after LPS.
Regulation (regulation) of SOCS3 mRNA associated with cytokine
3) Confidence 0.26 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.54 Pain Relevance 0.46
Up-regulation of stress response (MAFK, IKBZ, SOCS3) and early growth response (c-Myc, c-Jun, c-Fos, DUSP1 and 6) genes as assessed by RT-qPCR and/or microarray profiling was unchanged.
Regulation (regulation) of SOCS3 associated with stress
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.19 Pain Relevance 0
SOCS3 values were log-transformed to normalize the distribution.
Regulation (values) of SOCS3
5) Confidence 0.24 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 0.07 Pain Relevance 0
Modulation of SOCS3 levels in T cells could be useful in regulating the Th1/Th2 balance for the treatment of autoimmune inflammatory diseases.


Regulation (Modulation) of SOCS3 in T cells associated with inflammation and disease
6) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.82 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox