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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.68
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
Socs2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 53 100.00 Very High Very High Very High
agonist 6 74.48 Quite High
gABA 51 73.08 Quite High
Paracetamol 1 70.88 Quite High
GABAergic 3 60.80 Quite High
Neurotransmitter 4 50.00 Quite Low
Eae 1 21.76 Low Low
Inflammation 34 5.00 Very Low Very Low Very Low
Bile 16 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 70 95.96 Very High Very High Very High
Liver Disease 1 85.52 High High
Starvation 2 84.32 Quite High
Obesity 21 84.00 Quite High
Targeted Disruption 55 81.48 Quite High
Stress 9 81.04 Quite High
Calcification 7 80.64 Quite High
Body Weight 3 78.64 Quite High
Toxicity 3 69.76 Quite High
Leukemia 3 69.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To some degree, inhibition of Lif/Lifr signaling may be countered in long-lived mice by down-regulation of Socs2 (suppressor of cytokine signaling) [47,48], which was also down-regulated in all four long-lived dwarf models.
Negative_regulation (regulation) of Socs2 associated with cytokine
1) Confidence 0.31 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.67 Pain Relevance 0.16
From an analysis of KO mice, SOCS2 has been shown to be a relatively specific negative regulator of GH–STAT5 [13,14].
Negative_regulation (regulator) of SOCS2
2) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.05 Pain Relevance 0.13
Because TM and CM are smooth muscle-like, we hypothesized that regulator of G-protein signaling 2 (RGS2), a regulatory protein that promotes vascular smooth muscle relaxation and blood pressure homeostasis [12-15], might control IOP.
Negative_regulation (regulator) of signaling 2 in blood associated with ocular hypertension
3) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2650719 Disease Relevance 0.19 Pain Relevance 0.07
Fgf21 also induces the hepatic expression of genes encoding IGF-1-binding protein 1 and suppressor of cytokine signaling 2, which blunt growth hormone signaling (Inagaki et al. 2008).
Negative_regulation (suppressor) of cytokine signaling 2 associated with cytokine
4) Confidence 0.02 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.64 Pain Relevance 0.05
D-2-HG is derived from GHB in a reaction catalyzed by d-2-hydroxyglutarate transhydrogenase (HOT), an enzyme known to manifest a developmental ontogeny in the rodent [31,32].
Negative_regulation (derived) of D-2-HG
5) Confidence 0.02 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.13 Pain Relevance 0.10

General Comments

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