INT184042

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 8.10
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Socs1)
Anatomy Link Frequency
joint 1
peritoneal macrophages 1
Socs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 220 100.00 Very High Very High Very High
tolerance 96 99.72 Very High Very High Very High
Inflammation 156 98.96 Very High Very High Very High
Arthritis 17 98.56 Very High Very High Very High
rheumatoid arthritis 90 96.16 Very High Very High Very High
Osteoarthritis 21 81.92 Quite High
cINOD 4 60.96 Quite High
anesthesia 2 23.92 Low Low
fibrosis 8 22.84 Low Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rabies Virus Infection 4 99.82 Very High Very High Very High
Encephalitis 30 99.72 Very High Very High Very High
Cancer 56 99.28 Very High Very High Very High
Hepatocellular Cancer 36 99.26 Very High Very High Very High
Cold Sores 2 99.12 Very High Very High Very High
Arthritis 25 98.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 98.84 Very High Very High Very High
Obesity 12 98.36 Very High Very High Very High
Targeted Disruption 52 98.16 Very High Very High Very High
Diabetes Mellitus 19 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a murine model of autoimmune arthritis, joint inflammation and destruction was significantly enhanced in mice lacking SOCS1 [71,72].
Negative_regulation (lacking) of SOCS1 in joint associated with inflammation and arthritis
1) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.18 Pain Relevance 0.60
SOCS1 may inhibit the development and/or progression of hepatocellular carcinoma (HCC), because SOCS1 expression is significantly reduced in HCC cells; this can be explained by the inactivation of the SOCS1 promoter due to hypermethylation of CpG islands [81,82].
Negative_regulation (inactivation) of SOCS1 associated with hepatocellular cancer
2) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.95 Pain Relevance 0.18
A decrease in SOCS1 and SOCS3 by antisense RNA treatment in obese diabetic mice improved insulin sensitivity and ameliorated hepatic steatosis and hypertriglyceridemia [100].
Negative_regulation (decrease) of SOCS1 associated with diabetes mellitus, obesity and hyperlipidemia
3) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.78 Pain Relevance 0.19
Moreover, LPS tolerance was severely impaired in SOCS1-/- mice and SOCS1-deficient peritoneal macrophages [62,63].
Negative_regulation (impaired) of SOCS1 in peritoneal macrophages associated with tolerance
4) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.31 Pain Relevance 0.21
These results are similar to a study with rabies virus infection wherein downregulation of SOCS-1 gene was shown [44].
Negative_regulation (downregulation) of SOCS-1 gene associated with rabies virus infection
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 1.09 Pain Relevance 0.13
SOCS-1, the suppressor of cytokine signaling gene playing a critical role in the negative regulation of cytokine signaling was steadily decreasing after initial elevation.
Negative_regulation (decreasing) of SOCS-1 associated with cytokine
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 1.13 Pain Relevance 0.14
Loss of SOCS-1 results in constitutive PKR hyperactivity in naive cells, even in the absence of LPS stimulation.
Negative_regulation (Loss) of SOCS-1 associated with attention deficit hyperactivity disorder
7) Confidence 0.13 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.10 Pain Relevance 0.05
Why a loss of SOCS-1 results in dramatically and constitutively elevated levels of phosphorylated PKR, but not total PKR, is not entirely clear.
Negative_regulation (loss) of SOCS-1
8) Confidence 0.13 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.10 Pain Relevance 0.04
The deep sternal SSI could be significantly decreased (p<0.01) compared to the patients which received insulin intermittent subcutaneously.
Negative_regulation (decreased) of SSI
9) Confidence 0.07 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831242 Disease Relevance 0.82 Pain Relevance 0
However, in aggregate-containing tissues, rituximab significantly reduced total IgM and IgG SSI as well as IgM and IgG1 mRNA.
Negative_regulation (reduced) of SSI
10) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2592782 Disease Relevance 0.66 Pain Relevance 0.33

General Comments

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