INT184049

Context Info Confidence 0.40 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.54 Pain Relevance 0.53

extracellular space (Ighg2b)

Anatomy Link Frequency joint 2 Ighg2b (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 60 100.00 rheumatoid arthritis 10 99.50 Inflammation 38 96.08 fibrosis 2 83.76 Arthritis 4 74.96 cINOD 1 64.88 Crohn's disease 1 47.44 agonist 20 5.00 Buprenorphine 4 5.00 ketamine 2 5.00

Disease Link Frequency Relevance Heat Arthropathy 1 99.88 Rheumatoid Arthritis 10 99.50 INFLAMMATION 35 96.08 Adenoma 1 94.72 Disease 20 91.88 Fibrosis 1 83.76 Hyperplasia 1 81.96 Experimental Arthritis 1 74.96 Synovitis 1 64.08 Toxicity 1 52.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The NP-specific mAb S43-10 (Reth et al., 1978) was used as a positive control for a high-affinity NP-specific IgG2c antibody with an affinities of Kd = 2.4 × 10?

Positive_regulation (-) of Gene_expression (antibody) of IgG2c

1) Confidence 0.40 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.05 Pain Relevance 0

The NP-specific mAb S43-10 (Reth et al., 1978) was used as a positive control for a high-affinity NP-specific IgG2c antibody with an affinities of Kd = 2.4 × 10?

Positive_regulation (control) of Gene_expression (antibody) of IgG2c

2) Confidence 0.40 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.05 Pain Relevance 0

A mouse line of mutated gp130 in which the SHP-2/SOCS3-binding site was disrupted developed a RA-like joint disease with increased production of Th1-type cytokines and immunoglobulins of the IgG2a and IgG2b classes [78].

Positive_regulation (increased) of Gene_expression (production) of IgG2b in joint associated with rheumatoid arthritis, arthropathy and cytokine

3) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.43 Pain Relevance 0.53

General Comments

This test has worked.